干细胞治疗终末期肝病的进展与挑战

被引:10
作者
施明 [1 ]
刘振文 [1 ]
张政 [2 ]
王福生 [2 ]
机构
[1] 解放军医院肝移植研究中心
[2] 肝病生物治疗研究中心
关键词
干细胞; 肝移植; 肝疾病;
D O I
暂无
中图分类号
R575.3 [肝功能衰竭];
学科分类号
100201 [内科学];
摘要
干细胞包括胚胎干细胞和成体干细胞,具有无限自我更新能力,可以分化成特定组织,修复各种损伤。骨髓是成体干细胞的重要来源,主要含骨髓造血干细胞和间充质干细胞。目前利用干细胞治疗终末期肝病越来越受到关注。本文从体外、动物实验和临床研究三个方面总结了干细胞特别是成体干细胞治疗终末期肝病的研究进展,重点阐述各种来源干细胞在临床应用中取得的进展,探讨干细胞治疗终末期肝病的可能机制,提出目前研究存在的问题,展望未来的应用前景。
引用
收藏
页码:685 / 692
页数:8
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