CCL17在类风湿关节炎患者外周血清中的表达及意义

被引：7

作者：

崔东源

王晓非

机构：

[1] 中国医科大学附属盛京医院风湿免疫科

来源：

中国医科大学学报 | 2015年 / 44卷 / 10期

关键词：

类风湿关节炎; CCL17/TARC; 酶联免疫吸附试验;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

目的通过检测类风湿关节炎(RA)患者外周血清中CCL17的表达水平,探讨其在RA发病中的意义。方法采用酶联免疫吸附试验(ELISA)检测40例类风湿关节炎(RA)患者和20例正常对照组血清CCL17水平,记录被检者同批次实验室指标及相关临床表现,计算RA疾病活动评分(DAS28),并进行统计学分析。结果 RA组患者血清CCL17水平高于正常对照组,差异有统计学意义(P<0.05)。高度疾病活动RA患者组(DAS28≥5.1)血清CCL17水平高于中度疾病活动RA患者组(3.2≤DAS28<5.1),差异有统计学意义(P<0.05)。RA患者组血清CCL17水平与患者C反应蛋白、抗环瓜氨酸多肽抗体、血小板计数呈正相关,差异有统计学意义(P<0.05)。结论 RA患者外周血清CCL17水平较正常对照组升高,且与疾病活动指标具有一定的相关性,提示CCL17可能参与了RA的发生及疾病进展过程。

引用

页码：913 / 916+920 +920

页数：5

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