多元醇通路:糖尿病性白内障药物干预的重要靶标

被引：2

作者：

张秋艳

龚晓健

机构：

[1] 中国药科大学药理学教研室

来源：

药学进展 | 2013年 / 37卷 / 04期

关键词：

糖尿病性白内障; 多元醇通路; 渗透应激; 氧化应激; 醛糖还原酶抑制剂; 抗氧化作用;

D O I：

暂无

中图分类号：

R776.1 [白内障];

学科分类号：

100212 ;

摘要：

白内障是导致失明的主要因素,也是糖尿病的主要并发症之一。目前糖尿病性白内障的发病机制尚不十分明确,而多元醇通路的激活可导致渗透应激和氧化应激等一系列反应,被认为在糖尿病性白内障病理过程中发挥重要作用。简述多元醇通路在糖尿病性白内障发生发展中所起的作用,介绍近年来以多元醇通路中醛糖还原酶作为靶点的糖尿病性白内障治疗药物的研究进展。

引用

页码：145 / 152

页数：8

共 24 条

[1]

Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro[J]. Rajesh Kumar,Dinesh Kumar Patel,Damiki Laloo,Krishnamurthy Sairam,Siva Hemalatha.Asian Pacific Journal of Tropical Medicine. 2011(09)

[2]

Identification of flavonoids and flavonoid rhamnosides from Rhododendron mucronulatum for. albiflorum and their inhibitory activities against aldose reductase[J] . So-Youn Mok,Sanghyun Lee.Food Chemistry . 2013 (2)

[3]

Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F. Muell[J] . DK Patel,R Kumar,M Kumar,K Sairam,S Hemalatha.Asian Pacific Journal of Tropical Biomedicine . 2012 (2)

[4]

Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro[J] . Rajesh Kumar,Dinesh Kumar Patel,Damiki Laloo,Krishnamurthy Sairam,Siva Hemalatha.Asian Pacific Journal of Tropical Medicine . 2011 (9)

[5] Effect of streptozocin-induced diabetes mellitus on expression of methionine sulfoxide reductases and accumulation of their substrates in mouse lenses [J].

Li, Yi ;

Zhang, Wen ;

Li, Peiwu ;

Huang, Kaixun .

EXPERIMENTAL EYE RESEARCH, 2011, 92 (05) :401-407

[6]

DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice[J] . European Journal of Pharmacology . 2011 (1)

[7]

Aldose reductase deficiency protects sugar-induced lens opacification in rats[J] . Aramati B.M. Reddy,Ravinder Tammali,Rakesh Mishra,Shriram Srivastava,Satish K. Srivastava,Kota V. Ramana.Chemico-Biological Interactions . 2011 (1)

[8]

Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: An attempt to standardize the botanicals for amelioration of diabetes complications[J] . R.N. Gacche,N.A. Dhole.Food and Chemical Toxicology . 2011 (8)

[9] Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold [J].

Chen, Xin ;

Yang, Yanchun ;

Ma, Bing ;

Zhang, Shuzhen ;

He, Minlan ;

Gui, Dequan ;

Hussain, Saghir ;

Jing, Chaojun ;

Zhu, Changjin ;

Yu, Qun ;

Liu, Yan .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (05) :1536-1544

[10]

Quercitrin gallate inhibits aldose reductase activity and xylose-induced lens opacity and oxidation[J] . Young Sook Kim,Nan Hee Kim,Nam Hee Yoo,Yun Mi Lee,Il-Ha Jeong,Jin Sook Kim.Biomedicine & Aging Pathology . 2011 (2)

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