药物性肝损伤相关基因多态性研究现状

被引：3

作者：

任悦

潘晨

沈素

机构：

[1] 首都医科大学附属北京友谊医院药学部

来源：

中国临床药理学杂志 | 2019年 / 35卷 / 24期

关键词：

药物性肝损伤; 基因多态性; 机制; 流行病学;

D O I：

10.13699/j.cnki.1001-6821.2019.24.023

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

药物性肝损伤(drug-induced liver injury,DILI)指使用一种或多种药物后,由药物或其代谢产物引起的肝脏损伤,轻者停药后可自行恢复,重者可能危及生命。近年来对DILI危险因素研究较多,其中基因多态性成为热点。本文从DILI的流行病学、发病机制、临床分型以及药物基因组学几个方面进行综述,重点介绍了细胞色素P450单加氧酶(Cytochrome P450,CYP450)、尿核苷二磷酸葡萄糖醛酸转移酶(UDP-glucuronosyltransferase,UGT)、N-乙酰转移酶-2(N-acetyltransferase-2,NAT2)和人类白细胞抗原(human leukocyte antigen,HLA)的基因多态性和DILI的关系。

引用

页码：3257 / 3260

页数：4

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