胃癌及癌旁组织中p53基因和Rb基因的研究

被引:3
作者
王俊茹
刘为纹
王冰
吕有勇
邓国仁
机构
[1] 第三军医大学西南医院消化科
[2] 北京市肿瘤研究所
关键词
胃肿瘤; 致癌基因; p53基因; Rb基因;
D O I
10.16016/j.1000-5404.1993.03.003
中图分类号
学科分类号
摘要
本文使用Southern杂交方法分析了胃癌组织中p53基因和Rb基因的缺失和重排;使用PCR-RFLP技术分析了p53基因第248位、249位密码子的点突变。研究结果显示:30例胃癌组织中9例有p53基因的缺失或重排;42例胃癌组织中两例有p53基因第248位密码子的点突变;15例胃癌组织中两例有Rb基因的缺失和重排。
引用
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页码:198 / 202
页数:5
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