槲皮素抗肿瘤的分子机制研究进展

被引:33
作者
王刚 [1 ,2 ]
杜士明 [1 ]
杨光义 [1 ]
曾南 [2 ]
机构
[1] 郧阳医学院附属太和医院药学部
[2] 成都中医药大学
关键词
槲皮素; 抗肿瘤; 分子机制; 研究进展;
D O I
暂无
中图分类号
R285 [中药药理学];
学科分类号
1008 ;
摘要
目的:通过介绍槲皮素抗肿瘤的分子机制研究进展,阐明槲皮素抗肿瘤作用的多环节、多靶点性,为槲皮素抗肿瘤的应用研究提供新的研究方法和思路。方法:将国内外学者在槲皮素抗肿瘤的基因调控、信号转导和逆转多药耐药等方面分子机制研究成果和研究现状做一全面阐述,探讨槲皮素抗肿瘤的研究方向和切入点。结果:从分子水平和作用靶点研究槲皮素抗肿瘤作用具有重要的理论意义和实用价值。结论:槲皮素在抗癌作用方面具有广泛的应用前景和开发价值,今后应深入研究其抗肿瘤的作用机制及临床应用。
引用
收藏
页码:322 / 324
页数:3
相关论文
共 11 条
[1]   槲皮素对肺腺癌A549细胞生长的影响 [J].
王箭 ;
张鹏辉 ;
涂植光 .
第三军医大学学报, 2007, (19) :1852-1854
[2]   Quercetin Induces Oxidative Stress and Potentiates the Apoptotic Action of 2-Methoxyestradiol in Human Hepatoma Cells [J].
Chang, Yuh-Fang ;
Hsu, Yi-Chiung ;
Hung, Hui-Fang ;
Lee, Hui-Ju ;
Lui, Wing-Yiu ;
Chi, Chin-Wen ;
Wang, Jane-Jen .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2009, 61 (05) :735-745
[3]   Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells [J].
Min, Kyungmi ;
Ebeler, Susan E. .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (11) :2716-2722
[4]   Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening [J].
Lee, Su-Jin ;
Jung, Youn-Sang ;
Lee, Sun-Hye ;
Chung, Hye-Young ;
Park, Bum-Joon .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (06) :1637-1643
[5]  
The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC)[J] . Cellular & Molecular Biology Letters . 2009 (3)
[6]  
Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway[J] . Young-Ho Kim,Dae-Hee Lee,Jae-Hoon Jeong,Zong Sheng Guo,Yong J. Lee.Biochemical Pharmacology . 2008 (10)
[7]   Multitargeted cancer prevention by quercetin [J].
Murakami, Akira ;
Ashida, Hitoshi ;
Terao, Junji .
CANCER LETTERS, 2008, 269 (02) :315-325
[8]  
Inhibition of cyclooxygenase-2 and telomerase activities in human leukemiacells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosiasp[J] . Cheol Park,Jee Jung,Nam Kim,Yung Choi.International Journal of Oncology . 2007 (1)
[9]  
Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells[J] . Tong-Jong Chen,Jing-Yueh Jeng,Cheng-Wei Lin,Chin-Yen Wu,Yen-Chou Chen.Toxicology . 2006 (1)
[10]  
New and Old Functions of STAT3: A Pivitol Target for Individualized Treatment of Cancer[J] . G. Inghirami,R. Chiarle,W.J. Simmons,R. Piva,K. Schlessinger,D.E. Levy.Cell Cycle . 2005 (9)