细胞自噬调控的分子机制研究进展

被引：67

作者：

李乐兴

戴汉川

机构：

[1] 华中农业大学动物医学院,基础兽医学系动物生物化学教研室

来源：

中国细胞生物学学报 | 2015年 / 37卷 / 02期

关键词：

细胞自噬; 泛素化; mTOR; microRNA; caspase; 分子调控;

D O I：

暂无

中图分类号：

Q25 [细胞生理学];

学科分类号：

071003 [生理学];

摘要：

细胞自噬是一种进化上保守的分解代谢过程,涉及细胞内长寿命蛋白和受损伤细胞器的降解,其在细胞内稳态、肿瘤、心力衰竭、衰老相关性疾病、神经退行性疾病以及传染病等多种生命进程中发挥着重要作用。泛素样蛋白系统、m TOR信号通路、micro RNA、caspase等均参与了细胞自噬调控过程。该文综述了细胞自噬过程、功能和分子调控机制的研究进展,以期有助于研究细胞自噬机理,为治疗心脏疾病(如动脉粥样硬化)、癌症(如乳腺癌)等提供理论基础。

引用

页码：263 / 270

页数：8

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