细胞表面抗原抗体相关脑炎

被引：9

作者：

王佳伟

宋兆慧

机构：

[1] 首都医科大学附属北京友谊医院神经内科

来源：

中国实用内科杂志 | 2012年 / 32卷 / 11期

关键词：

神经元表面抗原抗体; AMPA受体; NMDA受体; GABAB受体; LGI1; Caspr2;

D O I：

暂无

中图分类号：

R512.3 [脑炎及脑脊髓膜炎];

学科分类号：

100201 [内科学];

摘要：

由于人们对细胞表面抗原抗体相关脑炎的认识不足,延误诊治,对其预后造成不良影响。细胞表面抗原抗体相关脑炎的靶抗原,在突触传递、重塑和神经兴奋方面起着重要作用,包括N-甲基-D天冬氨酸(NMDA)受体、α-氨基-3-羟基-5-甲基-4-异恶唑基丙酸(AMPA)受体、γ-氨基丁酸B(GABAB)受体和其他自身抗原,如LGI1和Caspr2等。该类疾病主要涉及儿童和年轻人,病情较重,病程较长,可伴或不伴发肿瘤,早期治疗后预后较好,但存在复发趋势。文章旨在阐述该类疾病临床特征,诊断和治疗的新进展,以引起临床医生的关注。

引用

页码：826 / 829

页数：4

共 12 条

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许春伶 ;

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[2]

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