铜绿假单孢菌多药外排系统研究进展

被引:7
作者
田睿
机构
[1] 中国协和医科大学中国医学科学院医药生物技术研究所北京
关键词
铜绿假单孢菌; 外排泵; MexAB-OprM;
D O I
10.13461/j.cnki.wna.003865
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
铜绿假单孢菌是一种重要的院内感染条件致病菌 ,具有先天的和后天获得的多重高度耐药性 ,一旦感染 ,临床治疗十分困难。铜绿假单孢菌的耐药机理十分复杂 ,除常见耐药机制外 ,很重要的就是其拥有可以外排多种药物的主动外排系统 ,使抗菌药物很难发挥应有作用。本文将从近年铜绿假单孢菌中各类外排泵的研究情况 ,特别是其中最重要的外排系统“MexAB -OprM”的分子结构模型、膜定位、该基因的表达与调控等方面的研究进展做一综述。
引用
收藏
页码:168 / 171
页数:4
相关论文
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