作用于Bcl-2家族抗凋亡亚族蛋白的小分子抑制剂的研究进展

被引:21
作者
汤湧
张大永
吴晓明
机构
[1] 中国药科大学药学院
关键词
Bcl-2; 抑制剂; 凋亡; 药物设计;
D O I
暂无
中图分类号
R979.1 [抗肿瘤、抗癌药物];
学科分类号
100403 [营养与食品卫生学];
摘要
细胞的凋亡是维持机体平衡的重要因素。细胞凋亡由一系列细胞因子调控。Bcl-2蛋白家族是细胞凋亡的关键性调节因子。Bcl-2家族分为抗凋亡和促凋亡两个亚族,他们的相互作用对细胞凋亡信号传导起调控作用。很多肿瘤细胞高表达Bcl-2抗凋亡亚族成员Bcl-2/Bcl-xL。近年来,随着Bcl-2家族各成员的晶体结构相继阐明,人们开始寻找作用于Bcl-2家族抗凋亡亚族蛋白的小分子抑制剂。本文从药物设计角度对该方面的进展作一综述。
引用
收藏
页码:669 / 677
页数:9
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