陈皮、青皮中4种黄酮成分的比较研究

被引:66
作者
邱蓉丽
吴玉兰
乐巍
机构
[1] 南京中医药大学
关键词
陈皮; 青皮; 黄酮; 橙皮苷; 柚皮苷; 川陈皮素; 橘皮素;
D O I
暂无
中图分类号
R284.1 [化学分析与鉴定];
学科分类号
100804 [中药化学];
摘要
目的比较浙江、湖北、广东产陈皮、青皮药材中橙皮苷、柚皮苷、川陈皮素和橘皮素的量。方法用甲醇超声提取药材,HPLC法测定,采用Waters xbridge C18色谱柱(150 mm×4.6 mm,5μm);流动相为乙腈-0.5%醋酸水,梯度洗脱(0~20 min,10%25%乙腈;20~35 min,25%70%乙腈;35~38 min,70%95%乙腈);体积流量1m L/min;柱温30℃;检测波长283 nm。结果陈皮、青皮药材中4种黄酮类成分均以橙皮苷含有量为最高,柚皮苷含有量最低;浙江和湖北产陈皮和青皮中橙皮苷的含有量均符合《中国药典》标准,但两地的青皮中川陈皮素和橘皮素的量要远大于陈皮。广东新会产陈皮和青皮中橙皮苷的含有量均偏低,但它们的川陈皮素和橘皮素的含有量相差不大。结论陈皮和青皮中黄酮类成分含有量的差异可用于解释它们功效之间的区别。
引用
收藏
页码:149 / 153
页数:5
相关论文
共 10 条
[1]
HPLC法同时测定不同产地广陈皮中5种活性黄酮成分 [J].
郑国栋 ;
蒋林 ;
杨得坡 ;
周芳 ;
杨雪 ;
林乐维 .
中草药, 2010, (04) :652-655
[2]
陈皮的药用研究进展 [J].
李庆耀 ;
梁生林 .
中成药, 2008, (02) :246-248
[3]
Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo [J].
Ma, Xiuying ;
Jin, Shaoju ;
Zhang, Yuanyuan ;
Wan, Lihong ;
Zhao, Yanyan ;
Zhou, Liming .
PHYTOTHERAPY RESEARCH, 2014, 28 (04) :560-567
[4]
Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells [J].
Shi, Ming-Der ;
Liao, Yi-Chen ;
Shih, Yuan-Wei ;
Tsai, Li-Yu .
PHYTOMEDICINE, 2013, 20 (8-9) :743-752
[5]
Nobiletin Induces Apoptosis and Potentiates the Effects of the Anticancer Drug 5-Fluorouracil in p53-Mutated SNU-16 Human Gastric Cancer Cells [J].
Moon, Jeong Yong ;
Cho, Moonjae ;
Ahn, Kwang Seok ;
Cho, Somi Kim .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 (02) :286-295
[6]
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? [J].
Walle, Thomas .
SEMINARS IN CANCER BIOLOGY, 2007, 17 (05) :354-362
[7]
Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques [J].
Wang Dandan ;
Wang Jian ;
Huang Xuehui ;
Tu Ying ;
Ni Kunyi .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 44 (01) :63-69
[8]
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.[J].Karen L. Morley;Peter J. Ferguson;James Koropatnick.Cancer Letters.2006, 1
[9]
Anti‐tumour effects of nobiletin; a citrus flavonoid; on gastric cancer include: antiproliferative effects; induction of apoptosis and cell cycle deregulation.[J].N.Yoshimizu;Y.Otani;Y.Saikawa;T.Kubota;M.Yoshida;T.Furukawa;K.Kumai;K.Kameyama;M.Fujii;M.Yano;T.Sato;A.Ito;M.Kitajima.Alimentary Pharmacology & Therapeutics.2004,
[10]
中华人民共和国药典.[M].国家药典委员会; 编.中国医药科技出版社.2010,