Effect of 1,25-dihydroxyvitamin D3 on preventing allograft from acute rejection following rat orthotoic liver transplantation

被引：4

作者：

Ai-Bin Zhang Shu-Sen Zheng Chang-Ku Jia Yan Wang Department of Hepatobiliary Pancreatic Surgery

机构：

来源：

World Journal of Gastroenterology | 2003年 / 9卷 / 05期

关键词：

of; as; In; cell; from; Effect of 1,25-dihydroxyvitamin D3 on preventing allograft from acute rejection following rat orthotoic liver transplantation; were; in; BIL; for; with;

D O I：

暂无

中图分类号：

R657.3 [肝及肝管];

学科分类号：

1002 ; 100210 ;

摘要：

AIM:To study the mechanism and the preventive role of 1,25-dihydroxyvitamin D3 in acute rejection followingorthotopic liver transplantation.METHODS:Rats were randomly divided as donors orrecipients for orthotopic liver allotransplantation model.Fourgroups were designed in the study,Group Ⅰ:syngenic control(Wistar to Wistar);Group Ⅱ:acute rejection (SD to Wistar);Group Ⅲ:acute rejection treated with cyclosporine A,andGroup Ⅳ:acute rejection treated with 1,25-(OH)2D3.Liverfunction,rejection activity index and mRNA of IFN-γ,IL-10intragraft in recipients were measured on day 1,5,7,15,30 posttransplant for assessing graft function,severity ofacute rejection and immune state of recipients.RESULTS:Survival time of recipients in Group Ⅳ wassignificantly prolonged (4/6 recipients survived for over 100days.vs Group Ⅱ,P<0.001;vs Group Ⅲ,P>0.05).Aftertreatment with 1,25-(OH)2 DS,mean value of all the assaytested on each experimental time was compared,liverfunction in group IV was significantly improved (AST 127±41U/L-360±104 U/L,BIL 13±5 mmol/l-38±11 mmol/l;vsGroupⅡ,P<0.05;vs Group Ⅲ,P>0.05.Rejection activity indexwas significantly decreased (0-3.3±1.6;vsGroup Ⅱ,P<0.05;vsGroup Ⅲ,P>0.05).Level of hepatic IFN-γ mRNA in groupⅣ was decreased,while level of hepatic IL-10 mRNA wasincreased (vsGroup Ⅱ,P<0.05;vsGroup Ⅲ,P>0.05).CONCLUSION:Our results indicated that 1,25-(OH)2D3induced the secretion of cytokine toward to Th2 type,whichwould alleviate acute rejection,protect liver function andprolong survival of recipient after orthotopic liver transplantation.

引用

页码：1067 / 1071

页数：5

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