炎症因子TNF-α、IL-6、IL-17与类风湿关节炎并发动脉粥样硬化的关系

被引：101

作者：

陈英 ^{[1
]}

张文玲 ^{[1
]}

黄涛 ^{[2
]}

苏屿 ^{[2
]}

吴佳力 ^{[2
]}

机构：

[1] 中南大学湘雅医学院医学检验系

[2] 海南省人民医院检验科

来源：

免疫学杂志 | 2017年 / 03期

关键词：

肿瘤坏死因子-α; 白细胞介素6; 白细胞介素17; 类风湿性关节炎; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎]; R543.5 [动脉疾病]; R446.1 [生物化学检验、临床检验];

学科分类号：

100201 [内科学]; 100208 [临床检验诊断学];

摘要：

目的探讨血清肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、白细胞介素17(IL-17)与类风湿关节炎并发动脉粥样硬化的关系。方法收集我院治疗的268例活动期类风湿性关节炎合并动脉粥样硬化的患者,应用酶联免疫吸附试验(ELISA)检测血清中TNF-α、IL-6、IL-17的水平,采集临床资料,同时完善颈部血管彩超及冠状动脉CTA,评估动脉粥样硬化程度。结果观察组和对照组在性别、RA病程等一般资料方面进行比较,差异无统计学意义(P>0.05),2组患者在年龄、吸烟史、胆固醇、甘油三酯水平等一般资料方面同样不存在统计学差异(P>0.05)。观察组TNF-α、IL-6、IL-17的水平明显高于对照组,差异均有统计学意义(P<0.05),通过多因素Logistic回归分析,TNF-α、IL-17、IL-6与类风湿性关节炎并发动脉粥样硬化均有相关性,P值均小于0.05。结论肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、白细胞介素17(IL-17)在类风湿关节炎早发动脉粥样硬化患者中均高表达,可能共同参与了此类患者中动脉粥样硬化的发病过程。

引用

页码：268 / 272

页数：5

共 15 条

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