2016年脓毒症最新定义与诊断标准:回归本质 重新出发

被引:66
作者
薄禄龙
卞金俊
邓小明
机构
[1] 上海市,第二军医大学长海医院麻醉科
关键词
脓毒症; 休克, 脓毒性; 诊断;
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
脓毒症是导致危重病患者死亡的主要原因之一。脓毒症和脓毒性休克的定义于1991年提出, 于2001年修订。随着研究者对脓毒症病理生理机制研究的深入, 以及脓毒症临床治疗的不断改观, 美国重症医学会与欧洲重症医学会于2016年2月对脓毒症和脓毒性休克的定义予以更新。本文将回顾脓毒症定义的历史沿革, 介绍脓毒症和脓毒性休克的最新定义, 并展望该定义将产生的重要影响。脓毒症和脓毒性休克的最新定义和诊断标准, 将为相关临床研究提供重要参考依据, 有望在早期识别和治疗脓毒症患者中发挥关键作用。
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共 11 条
[1]
2015重症医学回顾与展望[J] 黄伟;孟玉兰; 中华危重病急救医学 2016, 01
[2]
Sepsis: older and newer concepts[J] Jean-Louis Vincent;Jean-Paul Mira;Massimo Antonelli The Lancet Respiratory Medicine 2016,
[3]
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)[J] Mervyn Singer;Clifford S. Deutschman;Christopher Warren Seymour;Manu Shankar-Hari;Djillali Annane;Michael Bauer;Rinaldo Bellomo;Gordon R. Bernard;Jean-Daniel Chiche;Craig M. Coopersmith;Richard S. Hotchkiss;Mitchell M. Levy;John C. Marshall;Greg S. Martin;Steven M. Opal;Gordon D. Rubenfeld;Tom van der Poll;Jean-Louis Vincent;Derek C. Angus JAMA 2016,
[4]
Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)[J] Manu Shankar-Hari;Gary S. Phillips;Mitchell L. Levy;Christopher W. Seymour;Vincent X. Liu;Clifford S. Deutschman;Derek C. Angus;Gordon D. Rubenfeld;Mervyn Singer JAMA 2016,
[5]
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)[J] Christopher W. Seymour;Vincent X. Liu;Theodore J. Iwashyna;Frank M. Brunkhorst;Thomas D. Rea;André Scherag;Gordon Rubenfeld;Jeremy M. Kahn;Manu Shankar-Hari;Mervyn Singer;Clifford S. Deutschman;Gabriel J. Escobar;Derek C. Angus JAMA 2016,
[6]
Systemic inflammatory response syndrome criteria in defining severe sepsis.[J] Kaukonen Kirsi-Maija;Bailey Michael;Pilcher David;Cooper D Jamie;Bellomo Rinaldo The New England journal of medicine 2015,
[7]
Trial of early; goal-directed resuscitation for septic shock.[J] Mouncey Paul R;Osborn Tiffany M;Power G Sarah;Harrison David A;Sadique M Zia;Grieve Richard D;Jahan Rahi;Harvey Sheila E;Bell Derek;Bion Julian F;Coats Timothy J;Singer Mervyn;Young J Duncan;Rowan Kathryn M The New England journal of medicine 2015,
[8]
Goal-directed resuscitation for patients with early septic shock.[J] Peake Sandra L;Delaney Anthony;Bailey Michael;Bellomo Rinaldo;Cameron Peter A;Cooper D James;Higgins Alisa M;Holdgate Anna;Howe Belinda D;Webb Steven A R;Williams Patricia The New England journal of medicine 2014,
[9]
A Randomized Trial of Protocol-Based Care for Early Septic Shock[J] The ProCESS Investigators The New England Journal of Medicine 2014,
[10]
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference[J] Mitchell M. Levy;Mitchell P. Fink;John C. Marshall;Edward Abraham;Derek Angus;Deborah Cook;Jonathan Cohen;Steven M. Opal;Jean-Louis Vincent;Graham Ramsay Intensive Care Medicine 2003,