颅脑损伤后炎症反应与脑水肿

被引：24

作者：

齐向前

于明琨

机构：

[1] 第二军医大学长征医院神经外科

来源：

中华神经医学杂志 | 2007年 / 6卷 / 08期

关键词：

颅脑损伤; 炎症反应; 脑水肿;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

摘要：

<正>创伤性脑水肿是创伤性脑损伤(traumatic brain injury,TBI)后的主要继发性病理生理过程之一,也是导致颅内压增高的主要原因。目前国内外多数学者主张将脑水肿分为血管源性、细胞毒性、渗透压性和脑积水性(间质性)四类。过去几十年,根据冷冻性脑损伤模型的研究结果,普遍认为创伤性

引用

页码：850 / 852

页数：3

共 7 条

[1] Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin-6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat [J].

Marklund, N ;

Keck, C ;

Hoover, R ;

Soltesz, K ;

Millard, M ;

LeBold, D ;

Spangler, Z ;

Banning, A ;

Benson, J ;

McIntosh, TK .

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 2005, 23 (01) :31-42

[2] Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats [J].

Nimmo, AJ ;

Cernak, I ;

Heath, DL ;

Hu, X ;

Bennett, CJ ;

Vink, R .

NEUROPEPTIDES, 2004, 38 (01) :40-47

[3] Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury [J].

He, J ;

Evans, CO ;

Hoffman, SW ;

Oyesiku, NM ;

Stein, DG .

EXPERIMENTAL NEUROLOGY, 2004, 189 (02) :404-412

[4] Effects of progesterone on the inflammatory response to brain injury in the rat [J].

Grossman, KJ ;

Goss, CW ;

Stein, DG .

BRAIN RESEARCH, 2004, 1008 (01) :29-39

[5]

Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury[J] . Schuhmann,Mokhtarzadeh,Stichtenoth,Skardelly,Klinge,Gutzki,Samii,Brinker.Neurological Research . 2003 (5)

[6]

Complement in central nervous system inflammation[J] . Scott R. Barnum.Immunologic Research . 2002 (1)

[7]

Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist .2 Tehranian R,Andell-Jonsson S,Beni SM,et al. Journal of Neurotrauma . 2002

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