颅脑外伤病人甲状腺激素水平与疾病严重程度及预后的关系

被引:6
作者
张文
杨涵铭
机构
[1] 上海医科大学附属华山医院急诊科!
关键词
甲状腺激素; 颅脑外伤; 严重程度; 预后;
D O I
暂无
中图分类号
R651.15 [];
学科分类号
摘要
目的研究颅脑外伤病人甲状腺激素水平与疾病严重程度及预后的关系。方法对例颅脑外伤病人的甲状腺激素水平与疾病的严重程度及预后的关系进行前瞻性研究。疾病的严重程度及预后分别采用GCS和GOS评分。入院第二天抽血查血清甲状腺激素(TT3、FT3、TT4、FT4、rT3和TSH)的浓度。结果GCS评分与TT3(r=0.4630,P<0.001)、FT3(r=0.442,P<0.01)和TT4(r=0.2994,P<0.05)的水平相关,与FT4和rT3无明显相关性。根据GCS评分结果分三组:①重度组(n=12):GCS3~8分;②中度组(n=11):GCS9~12分;③轻度组(n=24):GCS13~15分。三组的TT3(P<0.01)和FT3(P<0.01)值有差别,其中重度组和中度组的TT3和FT3水平分别比轻度组降低33.3%~35.5%和33.3%~34.7%。GOS评分与TT3(r=0.5756,P<0.001)、FT3(r=0.5017,P<0.001)和TT4(r=0.3984,P<0.01)的水平相关,与FT4、rT3和TSH无明显相关性。根据GOS评分结果分三组:①A组(n=8):死亡组;②B组(n=16):持续植物人状态和重度残废组;③C组(n=23):轻度残废和恢复良好组。三组的TT3(P<0.001)和FT3(P<0.01)值有差别,其中A组和B组的TT3和FT3水平分别比C组降低36.4%~45.0%和31.5%~40.3%
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页码:337 / 339
页数:3
相关论文
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