对乙酰氨基酚肝毒性生物标志物的研究进展

被引：6

作者：

陈华英 ^{[1
]}

张跃飞 ^{[2
]}

金若敏 ^{[1
]}

机构：

[1] 上海中医药大学药物安全评价研究中心

[2] 华润三九医药股份有限公司研发中心

来源：

中国药理学与毒理学杂志 | 2015年 / 29卷 / 01期

关键词：

对乙酰氨基酚; 肝毒性; 生物标志物;

D O I：

暂无

中图分类号：

R114 [卫生毒理];

学科分类号：

100235 [预防医学];

摘要：

对乙酰氨基酚(APAP)是目前临床应用最广泛的OTC类解热镇痛药,肝毒性是其主要不良反应之一。近年来对APAP肝毒性生物标志物的研究成为了热点,使用miRNA芯片、蛋白质组学、代谢组学等技术发现的新型生物标志物如循环miRNA和血清酶等,在临床和动物研究中都得到了广泛的关注,与经典生物标志物谷丙转氨酶和谷草转氨酶联合评价有利于提高预测和诊断药物性肝损伤的敏感性和特异性。本文结合APAP肝毒性机制的研究,对近年来发现的APAP肝毒性的生物标志物进行了分类描述,为临床应用APAP时出现肝毒性的早发现早治疗提供依据;同时供其他具有潜在肝毒性类药物的研究提供借鉴。

引用

页码：147 / 152

页数：6

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