高血压患者胱硫醚-β-合酶、硫化氢与颈动脉内膜中膜厚度的关系

被引：7

作者：

覃咏梅 ^{[1
]}

林玲 ^{[2
]}

王延博 ^{[1
]}

王蓓 ^{[2
]}

冯岚 ^{[3
]}

周莲 ^{[4
]}

机构：

[1] 广州医科大学研究生院

[2] 海南省第三人民医院心血管内科

[3] 海南省第三人民医院功能科

[4] 海南省第三人民医院检验科

来源：

中国动脉硬化杂志 | 2019年 / 27卷 / 05期

基金：

海南省自然科学基金;

关键词：

高血压; 同型半胱氨酸; 胱硫醚-β-合酶; 硫化氢; 颈动脉内膜中膜厚度; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

摘要：

目的探讨高血压患者血清胱硫醚-β-合酶（CBS）、硫化氢（H2S）水平与颈动脉内膜中膜厚度（CIMT）的相关性。方法对116例高血压患者,测量其血压、同型半胱氨酸（Hcy）、血脂四项（总胆固醇、低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白胆固醇）,并检测CBS、H2S水平和CIMT。依据Hcy水平将高血压患者分为H型高血压组（Hcy≥10μmol/L）和非H型高血压组（Hcy<10μmol/L）,比较两组Hcy、血脂、CBS、H2S、CIMT的差异。采用Pearson法分析各指标与CIMT之间的相关性。结果 H型高血压组患者CIMT高于非H型高血压组（P<0.05）,CBS、H2S水平均低于非H型高血压组（均P<0.05）。相关性分析结果显示:在高血压患者中,Hcy与CIMT呈正相关（r=0.752,P<0.05）;CBS、H2S与Hcy呈负相关（r分别为-0.413、-0.698,均P<0.05）,与CIMT呈负相关（r分别为-0.518、-0.779,均P<0.05）。结论与非H型高血压患者相比,H型高血压患者颈动脉粥样硬化程度更明显。高血压患者的CBS、H2S与颈动脉粥样硬化密切相关,有望作为高血压患者动脉粥样硬化的早期预测指标。

引用

页码：417 / 420

页数：4

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