聚苯乙烯-g-(十八烷基聚氧乙烯)阻抗血小板粘附的研究

The platelet adhesion and protein(Fibrinogen and albumin) adsorption ontoamphiphilic polystyrene-graft-poly(ethylene oxide) (PS-g-PEO) and polystyrene-graft -ω-stearyl-poly(ethyleneoxide) (PS-G-SPEO) were investigated. It was found that the plateletadhesion on PS-g-SPEO was lower than that on PS-g-PEO. The PS-g-SPEO surface shows apreference for Albumin, while the PS-g-PEO surface absorbed Fibrinogen selectivelyu. Twoeffects of stearyl end group on PS-g-SPEO surface: (1) the lower surface free energe leadsto SPEO enrich at surface; (2) the stearyl end group absorbed albumin selectively, seems tocontribute to resistant the platelet adhesion. So the polymer surface modificed by both stearylgroup and poly(ethylene oxide) chain may be a new ideal way to improve material's bloodcompatibility.