妇科常见恶性肿瘤中自噬的研究进展

被引:20
作者
王铭远
汤小晗
卢美松
机构
[1] 哈尔滨医科大学附属第一医院妇产科
关键词
自噬; 生殖器肿瘤,女(雌)性; 宫颈肿瘤; 子宫内膜肿瘤; 卵巢肿瘤; Beclin1;
D O I
暂无
中图分类号
R737.3 [女性生殖器肿瘤];
学科分类号
100214 [肿瘤学];
摘要
妇科恶性肿瘤是女性常见的恶性疾病之一,严重影响女性的健康,主要包括宫颈癌、子宫内膜癌、卵巢癌、阴道癌和外阴癌五大主要类型。其中,以宫颈癌、子宫内膜癌和卵巢癌最为常见。治疗妇科肿瘤的方法通常包括手术、放疗和化疗。然而,其高患病率和高致死率以及对化疗耐药严重制约着妇科肿瘤治愈率的提高。近年来,随着对肿瘤研究的不断深入,另一种细胞死亡的生物学过程——自噬现象,逐渐受到重视。自噬对肿瘤的发生、发展具有非常重要的作用。此外,肿瘤细胞可以通过自噬增强其对化疗药物的敏感性。卵巢癌、子宫内膜癌及宫颈癌等常见妇科恶性肿瘤组织中都存在自噬现象。自噬为妇科肿瘤的治疗提供了一种新思路。通过对自噬反应的干预,有可能成为妇科肿瘤生物治疗中的新方向。
引用
收藏
页码:5 / 8
页数:4
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