Dipeptidyl peptidase-4: A key player in chronic liver disease

被引：18

作者：

Minoru Itou ^{[1
]}

Takumi Kawaguchi ^{[2
]}

Eitaro Taniguchi ^{[1
]}

Michio Sata ^{[2
]}

机构：

[1] Division of Gastroenterology,Department of Medicine,Kurume University School of Medicine,Kurume 830-0011,Japan

[2] Division of Gastroenterology,Department of Medicine and Department of Digestive Disease Information and Research,Kurume University School of Medicine,Kurume 830-0011,Japan

来源：

World Journal of Gastroenterology | 2013年 / 19卷 / 15期

关键词：

Incretin; Viral hepatitis; Insulin resistance; Steatohepatitis; Cancer; Sitagliptin; Vildagliptin; Alogliptin; Teneligliptin; Linagliptin;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor.

引用

页码：2298 / 2306

页数：9

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