质子泵抑制剂引发骨质疏松的病变机制和治疗策略

被引：8

作者：

衣淑华 ^{[1
]}

衣淑珍 ^{[2
]}

机构：

[1] 山东省栖霞市人民医院心内科

[2] 海军总医院药剂科

来源：

国际药学研究杂志 | 2012年 / 39卷 / 01期

关键词：

药物性骨质疏松; 抑酸剂; 质子泵抑制剂; 治疗策略;

D O I：

10.13220/j.cnki.jipr.2012.01.008

中图分类号：

R580 [];

学科分类号：

摘要：

质子泵抑制剂的长期使用会抑制机体对钙的吸收,从而干扰骨代谢、导致骨质疏松或骨折,对老年患者尤其明显。长期使用质子泵抑制剂导致骨折的风险可能与用药剂量和时间相关。目前对预防和治疗质子泵抑制剂引起的骨质疏松主要根据原发性骨质疏松的治疗原则而采取措施,对长期使用质子泵抑制剂的患者应补充钙剂和维生素D以预防骨质疏松,对于已导致的骨质疏松的患者可根据具体病情选择双膦酸盐、降钙素、雌激素和甲状旁腺类似物等治疗。本文对质子泵抑制剂引发骨质疏松的机制及预防和治疗策略的研究进展进行综述。

引用

页码：61 / 64

页数：4

共 10 条

[1] Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density
Genant, H. K.
Engelke, K.
Hanley, D. A.
Brown, J. P.
Omizo, M.
Bone, H. G.
Kivitz, A. J.
Fuerst, T.
Wang, H.
Austin, M.
Libanati, C.
[J]. BONE, 2010, 47 (01) : 131 - 139
[2] Proton Pump Inhibitors and Histamine-2 Receptor Antagonists Are Associated With Hip Fractures Among At-Risk Patients
Corley, Douglas A.
Kubo, Ai
Zhao, Wei
Quesenberry, Charles
[J]. GASTROENTEROLOGY, 2010, 139 (01) : 93 - 101
[3] The Antiresorptive Effects of a Single Dose of Zoledronate Persist for Two Years: A Randomized, Placebo-Controlled Trial in Osteopenic Postmenopausal Women[J] . Andrew Grey,Mark J. Bolland,Diana Wattie,Anne Horne,Greg Gamble,Ian R. Reid.The Journal of Clinical Endocrinology & Metabolism . 2009 (2)
[4] Increase in Vertebral Fracture Risk in Postmenopausal Women Using Omeprazole
Roux, Christian
Briot, Karine
Gossec, Laure
Kolta, Sami
Blenk, Tilo
Felsenberg, Dieter
Reid, David M.
Eastell, Richard
Glueer, Claus C.
[J]. CALCIFIED TISSUE INTERNATIONAL, 2009, 84 (01) : 13 - 19
[5] Acid-Suppressive Medications and Risk of Bone Loss and Fracture in Older Adults
Yu, Elaine W.
Blackwell, Terri
Ensrud, Kristine E.
Hillier, Teresa A.
Lane, Nancy E.
Orwoll, Eric
Bauer, Douglas C.
[J]. CALCIFIED TISSUE INTERNATIONAL, 2008, 83 (04) : 251 - 259
[6] Use of proton pump inhibitors and risk of osteoporosisrelated fractures
Targownik, Laura E.
Lix, Lisa M.
Metge, Colleen J.
Prior, Heather J.
Leung, Stella
Leslie, William D.
[J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2008, 179 (04) : 319 - 326
[7] Proton Pump Inhibitors, Histamine H 2 Receptor Antagonists, and Other Antacid Medications and the Risk of Fracture[J] . P. Vestergaard,L. Rejnmark,L. Mosekilde.Calcified Tissue International . 2006 (2)
[8] Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa
Ueyama, T
Shirasawa, N
Ito, T
Tsuruo, Y
[J]. LIFE SCIENCES, 2004, 74 (18) : 2327 - 2337
[9] Atrophic gastritis and intestinal metaplasia in Helicobacter pylori infection: The role of caga status[J] . M. Sozzi,M. Valentini,N. Figura,P. De Paoli,R.M. Tedeschi,A. Gloghini,D. Serraino,M. Poletti,A. Carbone.The American Journal of Gastroenterology . 1998 (3)
[10] Effect of omeprazole, an inhibitor of H + , K + -ATPase, on bone resorption in humans[J] . Kazutoshi Mizunashi,Yohtaro Furukawa,Kaichiro Katano,Keishi Abe.Calcified Tissue International . 1993 (1)

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