自噬稳态调控与阿尔茨海默病防治策略

被引：13

作者：

张莹

郭舒涵

房芳

何金生

彭向雷

机构：

[1] 北京交通大学理学院生命科学与生物工程研究院

来源：

生命科学 | 2014年 / 26卷 / 04期

关键词：

自噬; 阿尔茨海默病; β淀粉样肽;

D O I：

10.13376/j.cbls/2014050

中图分类号：

R749.16 [];

学科分类号：

摘要：

自噬是真核细胞中降解易聚集蛋白质的重要途径,以应激和损伤时更为显著。自噬与阿尔茨海默病(Alzheimer’s disease,AD)密切相关,在AD中起到"双刃剑"的作用,与致病性β淀粉样肽(Aβ)和细胞骨架相关tau蛋白的生成和代谢都有密切的关系。随着对自噬机制的深入了解,人们发现了自噬在AD病理过程中的调节作用。综述了自噬的基本机制、自噬与AD发病的互作关系以及如何从自噬的信号转导途径入手,调整AD自噬稳态及重平衡,从而探索新的AD治疗性药物靶标。

引用

页码：340 / 348

页数：9

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