新型抗血小板药物临床研究进展

被引:4
作者
万文辉
钱晓明
机构
[1] 南京军区南京总医院干部病房一科
关键词
血小板聚集抑制剂; P2型嘌呤受体拮抗剂; 蛋白酶激活受体-1;
D O I
暂无
中图分类号
R972 [心血管系统药物];
学科分类号
摘要
目前已认识到血小板在血栓形成中起关键作用。抗血小板药物能在血栓形成级联中多个位点阻断血小板黏附、活化、聚集。环氧化酶-1抑制剂阿司匹林在防止心血管事件方面有效,但远非理想。近年来,开发了许多新型的抗血小板药物,文章就新型抗血小板药物在临床应用进展情况进行综述。
引用
收藏
页码:796 / 798
页数:3
相关论文
共 13 条
[1]  
Basic principles of platelet biology and clinical implications. Angiolillo DJ,,Ueno M,Goto S. Circulation Journal . 2010
[2]  
Routine up-stream versus selective downstream administration of glycoproteinⅡb/Ⅲa inhibitors in patients with non-ST-elevation acute coro-nary syndromes. Sciahbasi A,Biondi-Zoccai G,Romagnoli E,et al. International Journal of Cardiology . 2010
[3]  
Effect of CYP2C19 andABCB1 single nucleotide polymorphisms on outcomes of treatmentwith ticagrelor versus clopidogrel for acute coronary syndromes. Wallentin L,James S,Storey RF,et al. The Lancet . 2010
[4]  
2011 ACCF/AHA fo-cused update of the guidelines for the management of patients withunstable angina/non-ST-elevation myocardial infarction(updatingthe 2007 guideline). Wright RS,Anderson JL,Adams CD,et al. Journal of the American College of Cardiology . 2011
[5]  
Double-dose versusstandard-dose clopidogrel and high-dose versus low-dose aspirin inindividuals undergoing percutaneous coronary intervention for acutecoronary syndromes(CURRENT-OASIS 7). Mehta SR,Tanguay JF,Eikelboom JW,et al. The Lancet . 2010
[6]  
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial[J] . Shamir R Mehta,Jean-Francois Tanguay,John W Eikelboom,Sanjit S Jolly,Campbell D Joyner,Christopher B Granger,David P Faxon,Hans-Jurgen Rupprecht,Andrzej Budaj,Alvaro Avezum,Petr Widimsky,Philippe Gabriel Steg,Jean-Pierre Bassand,Gilles Montalescot,Carlos Macaya,Giuseppe Di
[7]  
Ticagrelor versus clopidogrel in patients with acute coronary syndromes. Wallentin L,Becker RC,Budaj A,et al. The New England Journal of Medicine . 2009
[8]  
Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH 530348 for non-ST-segment elevation acute coronary syndrome. S Goto,T Yamaguchi,Y Ikeda,K Kato,H Yamaguchi,P Jensen. Journal of Atherosclerosis and Thrombosis . 2010
[9]  
Safety andtolerability of SCH530348in patients undergoing non-urgentpercutaneous coronary intervention:a randomised,double-blindplacebo-controlled phase II study. Becker RC,Moliterno DJ,Jennings LK,et al. The Lancet . 2009
[10]  
Effects of CYP2C19genotype on outcomes of clopidogrel treatment. ParéG,Mehta SR,Yusuf S,Anand SS,Connolly SJ,Hirsh J,Simonsen K,Bhatt DL,Fox KA,Eikelboom JW. The New England Journal of Medicine . 2010