OLETF大鼠自发性2型糖尿病动物模型研究概述

被引：17

作者：

陈婧 ^{[1
]}

易玮 ^{[1
]}

许能贵 ^{[1
]}

孙健 ^{[2
]}

蓝丹纯 ^{[1
]}

机构：

[1] 广州中医药大学针灸康复临床医学院

[2] 广东省中医院针灸科

来源：

广州中医药大学学报 | 2015年 / 32卷 / 01期

关键词：

OLETF大鼠; 自发性2型糖尿病; 胰岛素抵抗; 疾病模型,动物;

D O I：

10.13359/j.cnki.gzxbtcm.2015.01.041

中图分类号：

R587.1 [糖尿病]; R-332 [医用实验动物学];

学科分类号：

100201 [内科学]; 100402 [劳动卫生与环境卫生学];

摘要：

OLETF(Otsuka Long-Evans Tokushima Fatty)大鼠是1984年由日本大冢制药公司开发的自发性2型糖尿病鼠种。目前对该鼠的研究表明其特征表现如下:(1)慢性糖尿病(DM)病程;(2)多食;(3)轻度肥胖;(4)后期(18周后)出现高血糖;(5)胰腺增生;(6)肾并发症(结节病变);(7)内皮功能障碍;(8)胆囊收缩素1(CCK-1)受体m RNA的表达完全缺失,以及雄性遗传。该鼠早期以胰岛素抵抗、糖脂代谢紊乱为主,以后逐渐出现胰腺功能减退,晚期合并糖尿病肾脏病变,与人类2型糖尿病极为相似。

引用

页码：178 / 182

页数：5

共 17 条

[1]

Vascular Actions of Aldosterone [J].

Briet, Marie ;

Schiffrin, Ernesto L. .

JOURNAL OF VASCULAR RESEARCH, 2013, 50 (02) :89-99

[2]

Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats [J].

Siragy, Helmy M. ;

Xue, Chun .

EXPERIMENTAL PHYSIOLOGY, 2008, 93 (07) :817-824

[3]

Diurnal and nocturnal nursing behavior in the OLETF rat [J].

Schroeder, Mariana ;

Lavi-Avnon, Yael ;

Dagan, Michal ;

Zagoory-Sharon, Orna ;

Weller, Aron ;

Moran, Timothy H. .

DEVELOPMENTAL PSYCHOBIOLOGY, 2007, 49 (03) :323-333

[4]

Weight gain and maternal behavior in CCK1 deficient rats [J].

Schroeder, Mariana ;

Zagoory-Sharon, Orna ;

Lavi-Avnon, Yael ;

Moran, Timothv H. ;

Weller, Aron .

PHYSIOLOGY & BEHAVIOR, 2006, 89 (03) :402-409

[5]

The ontogeny of postingestive inhibitory stimuli: Examining the role of CCK [J].

Weller, Aron .

DEVELOPMENTAL PSYCHOBIOLOGY, 2006, 48 (05) :368-379

[6]

Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL).[J].Tetsuo Nishikawa;Sachiko Suematsu;Jun Saito;Akiko Soyama;Hiroko Ito;Tomoshige Kino;George Chrousos.Journal of Steroid Biochemistry and Molecular Biology.2005, 3

[7]

Vascular synthesis of aldosterone: role in hypertension.[J].Yoshiyu Takeda.Molecular and Cellular Endocrinology.2003, 1

[8]

Effects of Central and Peripheral Injection of Leptin on Food Intake and on Brain Fos Expression in the Otsuka Long‐Evans Tokushima Fatty Rat with Hyperleptinaemia.[J].Niimi;Sato;Yokote;Tada;Takahara.Journal of Neuroendocrinology.2001, 8

[9]

Acute tolerance to continuously infused alfentanil:: The role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems [J].

Kissin, I ;

Bright, CA ;

Bradley, EL .

ANESTHESIA AND ANALGESIA, 2000, 91 (01) :110-116

[10]

Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion [J].

Greenough, A ;

Cole, G ;

Lewis, J ;

Lockton, A ;

Blundell, J .

PHYSIOLOGY & BEHAVIOR, 1998, 65 (02) :303-310

← 1 2 →