异氟醚对健康志愿者脑葡萄糖代谢率的影响

被引：3

作者：

于代华

徐礼鲜

柴伟

张惠

林树新

徐海峰

姚立农

魏娟

机构：

[1] 第四军医大学唐都医院麻醉科

[2] 第四军医大学口腔医院麻醉科

[3] 第四军医大学基础部病理生理学教研室

[4] 第四军医大学唐都医院医学科

[5] 第四军医大学唐都医院护理保障中心西安市

[6] 西安市

来源：

中华麻醉学杂志 | 2004年 / 10期

关键词：

异氟烷; 脑; 葡萄糖;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的应用正电子发射断层扫描技术(PET),研究吸入不同浓度异氟醚麻醉对健康志愿者脑葡萄糖代谢率(CMRGlu)的影响。方法选择8名志愿者,每位志愿者分别做三次PET扫描,采用MASEP CPET Plus扫描仪及18F-FDG标记技术测定CMRGIu,第一次在清醒状态下扫描作为对照(清醒组),第二、三次分别吸入0.5 MAC和1.0MAC异氟醚(分别为0.5MAC组和1.0MAC组)后进行。结果清醒组全脑CMRGlu平均为(30.0±1.1)μmol·100mg-1·min-1,与清醒组比较,0.5MAC组降低全脑CMRGlu24%至(23.3±1.4)μmol·100 mg·min-1(P<0.05),1.0MAC组降低41％至(18.4±0.9)μmol·100mg-1·min-1(P<0.01);脑内各区葡萄糖代谢率(CMRGlu)均显著降低,而以丘脑、楔叶和扣带回降低更为显著(P<0.01);与0.5MAC组比较,1.0MAC组全脑及各脑区rCMRGu进一步降低(P<0.05)。结论全脑及脑内各区葡萄糖代谢率在吸入异氟醚麻醉时均可显著降低,丘脑、楔叶和扣带回对吸入异氟醚麻醉更为敏感。

引用

页码：13 / 16

页数：4

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