新生儿脑损伤生物学标志物研究进展

被引：19

作者：

邱洁

机构：

[1] 南京医科大学附属儿童医院新生儿医疗中心

来源：

中华实用儿科临床杂志 | 2017年 / 32卷 / 02期

关键词：

围生期窒息; 婴儿, 新生; 脑损伤; 生物学标志物; 激活素A; S100B蛋白;

D O I：

暂无

中图分类号：

R722.1 [新生儿疾病];

学科分类号：

100202 [儿科学];

摘要：

过去几十年, 生物学标志物作为无创工具在很多疾病的早期诊断及监测中被广泛应用。在围生医学, 随着高危新生儿的存活率增高, 越来越迫切需要可监测新生儿脑损伤的生物学标志物应用于临床。因为新生儿脑损伤的临床表现较为隐匿, 当临床表现和监测参数发生变化时往往已错过最佳治疗时机, 所以早期发现脑损伤的高危新生儿非常关键。这些生物学标志物的应用可使临床医师在疾病的早期即进行干预, 并监测这些干预的有效性。然而, 目前尚无足够充分的研究保证这些标志物常规应用于临床。现总结目前研究较多的生物学标志物, 如激活素A、S100B蛋白、胶质纤维酸性蛋白、肾上腺髓质素、神经特异性烯醇化酶、白细胞介素-6、转化生长因子-β、尿酸、有核红细胞、血红素氧化酶-1在监测新生儿脑损伤中的作用。

引用

共 62 条

[1]

Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns [J].

Sannia, Andrea ;

Zimmermann, Luc J. I. ;

Gavilanes, Antonio W. D. ;

Vles, Hans J. ;

Calevo, Maria Grazia ;

Florio, Pasquale ;

Gazzolo, Diego .

ACTA PAEDIATRICA, 2013, 102 (10) :E449-E454

[2]

Glial fibrillary acidic protein as a biomarker for periventricular white matter injury [J].

Stewart, Amanda ;

Tekes, Aylin ;

Huisman, Thierry A. G. M. ;

Jennings, Jacky M. ;

Allen, Marilee C. ;

Northington, Frances J. ;

Everett, Allen D. ;

Graham, Ernest M. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2013, 209 (01) :27.e1-27.e7

[3]

Nucleated Red Blood Cell in Cord Blood as a Marker of Perinatal Asphyxia [J].

Goel, Manjusha ;

Dwivedi, Rashmi ;

Gohiya, Poorva ;

Hegde, Deeparaj .

JOURNAL OF CLINICAL NEONATOLOGY, 2013, 2 (04) :179-182

[4]

Elevated Interleukin-6 Concentration and Alterations of the Coagulation System Are Associated with the Development of Intraventricular Hemorrhage in Extremely Preterm Infants [J].

Poralla, Christine ;

Hertfelder, Hans-Joerg ;

Oldenburg, Johannes ;

Mueller, Andreas ;

Bartmann, Peter ;

Heep, Axel .

NEONATOLOGY, 2012, 102 (04) :270-275

[5]

Neonatal Absolute Nucleated Red Blood Cell Counts do not Predict the Development of Cystic Periventricular Leukomalacia [J].

Marom, Ronella ;

Lubetzky, Ronit ;

Mimouni, Francis B. ;

Bassan, Haim ;

Ben Sira, Liat ;

Berger, Irnt ;

Dollberg, Shaul ;

Mandel, Dror .

ISRAEL MEDICAL ASSOCIATION JOURNAL, 2012, 14 (07) :420-423

[6]

Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling [J].

Ennen, Christopher S. ;

Huisman, Thierry A. G. M. ;

Savage, William J. ;

Northington, Frances J. ;

Jennings, Jacky M. ;

Everett, Allen D. ;

Graham, Ernest M. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2011, 205 (03)

[7]

Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonate.[J].Vineet Bhandari;Catalin S. Buhimschi;Christina S. Han;Sarah Y. Lee;Christian M. Pettker;Katherine H. Campbell;Antonette T. Dulay;Emily A. Oliver;Erika F. Werner;Irina A. Buhimschi.Journal of Maternal-Fetal and Neonatal Medicine.2011, 4

[8]

Maternal Serum Interleukin-6; C-Reactive Protein; and Matrix Metalloproteinase-9 Concentrations as Risk Factors for Preterm Birth <32 Weeks and Adverse Neonatal Outcomes.[J].Yoram Sorokin;Roberto Romero;Lisa Mele;Ronald Wapner;Jay Iams;Donald Dudley;Catherine Spong;Alan Peaceman;Kenneth Leveno;Margaret Harper;Steve Caritis;Menachem Miodovnik;Brian Mercer;John Thorp;Mary O'Sullivan;Susan Ramin;Marshall Carpenter;Dwight Rouse;Baha Sibai.Amer J Perinatol.2010, 08

[9]

Perinatal S100B Protein Assessment in Human Unconventional Biological Fluids: A Minireview and New Perspectives.[J].Diego Gazzolo;Fabrizio Michetti;Claus W. Heizmann.Cardiovascular Psychiatry and Neurology.2010,

[10]

Neuromarkers and unconventional biological fluids.[J].Diego Gazzolo;Raul Abella;Alessandro Frigiola;Alessandro Giamberti;Gabriella Tina;Francesco Nigro;Pasquale Florio;Micaela Colivicchi;Francesca Temporini;Alberto Ricotti;Giovanni Li Volti;Fabio Galvano.Journal of Maternal-Fetal and Neonatal Medicine.2010, S3

← 1 2 3 4 5 6 7 →