罗氟司特治疗慢性阻塞性肺疾病药理作用的临床前研究现况

被引:22
作者
冯桂山 [1 ]
宋宁 [2 ]
段争 [2 ]
吴雅莉 [2 ]
机构
[1] 易县人民医院内科
[2] 河北医科大学第二医院呼吸内科
关键词
肺疾病,慢性阻塞性; 罗氟司特; 药理作用;
D O I
暂无
中图分类号
R563.9 [其他];
学科分类号
100201 [内科学];
摘要
<正>慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种重要的致残、致死性疾病,已造成严重的社会经济负担。据世界卫生组织(WHO)统计,全球约超过2亿人罹患中度至重度COPD,2005年约3百万人因COPD死亡,占全球各种死亡原因的5%。至2030年COPD可能成为全
引用
收藏
页码:363 / 366
页数:4
相关论文
共 7 条
[1]
Theeffect of selective phosphodiesterase isoenzyme inhibitionon neutrophil functionin vitro..Jones NA;Boswell-Smith V;Lever R;Page CP;.Pulm PharmacolTher.2005, 02
[2]
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.[J].Stephen Field.Drug Design; Development and Therapy.2010, defa
[3]
The preclinical pharmacology of roflumilast – A selective; oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.[J].Armin Hatzelmann;Esteban J. Morcillo;Giuseppe Lungarella;Serge Adnot;Shahin Sanjar;Rolf Beume;Christian Schudt;Hermann Tenor.Pulmonary Pharmacology & Therapeutics.2010, 4
[4]
Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices.[J].Andrea Wohlsen;Andrea Hirrle;Hermann Tenor;Degenhard Marx;Rolf Beume.European Journal of Pharmacology.2010, 1
[5]
Pulmonary Vascular Involvement in COPD [J].
Peinado, Victor I. ;
Pizarro, Sandra ;
Barbera, Joan Albert .
CHEST, 2008, 134 (04) :808-814
[6]
Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial [J].
Hohlfeld, Jens M. ;
Schoenfeld, Kerstin ;
Lavae-Mokhtari, Mehyar ;
Schaumann, Frank ;
Mueller, Meike ;
Bredenbroeker, Dirk ;
Krug, Norbert ;
Hermann, Robert .
PULMONARY PHARMACOLOGY & THERAPEUTICS, 2008, 21 (04) :616-623
[7]
Molecular pathogenesis of emphysema [J].
Taraseviciene-Stewart, Lairnute ;
Voelkel, Norbert F. .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (02) :394-402