bcl-2反义脱氧寡核苷酸对白血病细胞生长与凋亡易感性的影响

被引:2
作者
陈协群
黄高升
杨平地
胡盛惠
机构
[1] 第四军医大学西京医院血液科!西安市
[2] 不详
[3] 第四军医大学西京医院病理学教研室
关键词
反义脱氧寡核苷酸; bcl-2基因; CEM细胞; 足叶乙甙; 凋亡;
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
摘要
研究证实,经10μmol/L,bcl-2特异的反义脱氧寡核苷酸处理3天后,T淋巴细胞白血病细胞株CEM的内源性bcl-2蛋白水平下降近50%,细胞存活率明显减少,对足叶乙甙的凋亡诱导效应亦更为敏感。表明,内源性bcl-2蛋白含量对促凋亡性化疗药物触发的白血病细胞死亡过程具有重要的影响。
引用
收藏
页码:9 / 12
页数:4
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