TNF-α与椎间盘退变关系的研究进展

被引：25

作者：

孙灰灰 ^{[1
]}

吴小涛 ^{[2
]}

机构：

[1] 东南大学医学院

[2] 东南大学附属中大医院骨科

来源：

东南大学学报(医学版) | 2015年 / 34卷 / 03期

关键词：

TNF-α; 椎间盘退变; 信号通路; 炎性反应; 文献综述;

D O I：

暂无

中图分类号：

R681.5 [脊柱及背疾病];

学科分类号：

100220 [骨科学];

摘要：

腰痛是骨科最常见症状之一,终板异常和椎间盘退变可能是椎间盘源性腰痛的病因。研究认为,退变腰椎终板与肿瘤坏死因子(TNF)-α的表达相关,TNF-α的高表达是产生疼痛的重要因素。作为能加速椎间盘退变的炎性因子,TNF-α在椎间盘退变过程中与其他基因产物有复杂的相互作用关系,目前已成为研究热点。作者就近几年国内外关于TNF-α与椎间盘退变关系的研究作一综述,进一步阐明TNF-α在椎间盘退变中的作用。

引用

页码：448 / 452

页数：5

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