CYP3A4和CYP3A5基因多态性对多西他赛药动学和药效学影响的研究进展

被引：6

作者：

赵苏

杨婉花

机构：

[1] 上海交通大学医学院附属瑞金医院药剂科

来源：

世界临床药物 | 2015年 / 36卷 / 09期

关键词：

多西他赛; CYP3A4; CYP3A5; 基因多态性;

D O I：

10.13683/j.wph.2015.09.015

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

多西他赛临床广泛应用于乳腺癌、非小细胞肺癌等多种癌症,主要在肝脏经CYP3A酶代谢,编码该酶的基因存在广泛的基因多态性,本文简要综述CYP3A4、CYP3A5基因多态性对多西他赛药动学和药效学影响的近年相关研究,供临床制定个体化给药方案参考。

引用

页码：640 / 644

页数：5

共 8 条

[1]

Assessment of clinical outcomes in breast cancer patients treated with taxanes: multi-analytical approach [J].

Tulsyan, Sonam ;

Chaturvedi, Pankaj ;

Singh, Abhishek Kumar ;

Agarwal, Gaurav ;

Lal, Punita ;

Agrawal, Sushma ;

Mittal, Rama Devi ;

Mittal, Balraj .

GENE, 2014, 543 (01) :69-75

[2]

Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy [J].

Kim, Kyu-pyo ;

Ahn, Jin-Hee ;

Kim, Sung-Bae ;

Jung, Kyung Hae ;

Yoon, Dok Hyun ;

Lee, Jung Shin ;

Ahn, Sei-Hyun .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 69 (05) :1221-1227

[3]

Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms [J].

Tsai, Shih-Meng ;

Lin, Chiou-Ya ;

Wu, Szu-Hsien ;

Hou, Linda Ann ;

Ma, Hsu ;

Tsai, Li-Yu ;

Hou, Ming-Feng .

CLINICA CHIMICA ACTA, 2009, 404 (02) :160-165

[4]

Ethnic differences in the distribution of CYP3A5 gene polymorphisms [J].

Quaranta, S. ;

Chevalier, D. ;

Allorge, D. ;

Lo-Guidice, J. M. ;

Migot-Nabias, F. ;

Kenani, A. ;

Imbenotte, M. ;

Broly, F. ;

Lacarelle, B. ;

Lhermitte, M. .

XENOBIOTICA, 2006, 36 (12) :1191-1200

[5]

Pharmacokinetics and pharmacodynamics of protein-unbound docetaxel in cancer patients [J].

Minami, H ;

Kawada, K ;

Sasaki, Y ;

Igarashi, T ;

Saeki, T ;

Tahara, M ;

Itoh, K ;

Fujii, H .

CANCER SCIENCE, 2006, 97 (03) :235-241

[6]

Phenotype–genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles.[J].Cristina Rodríguez-Antona;Jane G. Sayi;Lars L. Gustafsson;Leif Bertilsson;Magnus Ingelman-Sundberg.Biochemical and Biophysical Research Communications.2005, 1

[7]

Interindividual differences in hepatic expression of CYP3A4:: Relationship to genetic polymorphism in the 5′-upstream regulatory region [J].