肝纤维化中TGF-β/Smad信号通路研究进展

被引：24

作者：

于洋

史嘉翊

黄珍

刘增瑞

吴丹

机构：

[1] 牡丹江医学院医药研究中心

来源：

牡丹江医学院学报 | 2019年 / 40卷 / 05期

关键词：

肝纤维化; 转化生长因子β; Smad蛋白;

D O I：

10.13799/j.cnki.mdjyxyxb.2019.05.038

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

肝纤维化是多种病因导致的肝内结缔组织异常增生的一种疾病,主要由于细胞外基质增生速度超过降解速度并异常沉积,使肝脏结构和功能出现异常。肝纤维化的病变过程中,肝星状细胞的活化是关键环节,而转化生长因子β可以上调它合成细胞外基质。在多条细胞信号转导通路中,TGF-β/Smad信号转导通路是促进肝星状细胞活化合成细胞外基质的关键通路。本文针对在肝纤维化发生发展过程中TGF-β/Smad信号通路的相关研究动态进行综述。

引用

页码：121 / 123+174 +174

页数：4

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