利塞膦酸盐抗男性骨质疏松性骨折的效应

被引：2

作者：

钟招明

陈建庭

机构：

[1] 广州南方医科大学南方医院脊柱骨病外科

来源：

中国骨质疏松杂志 | 2007年 / 09期

关键词：

利塞膦酸盐; 骨质疏松; 荟萃分析; 骨折; 男性;

D O I：

暂无

中图分类号：

R580 []; R683 [骨折、骨的损伤];

学科分类号：

1002 ; 100201 ; 100210 ;

摘要：

目的系统评价利塞膦酸盐对男性骨质疏松的抗骨折效应。方法通过Medline数据库、EMBASE数据库、Cochrane图书馆和中国生物医学文献数据库检索1980-01至2006-12有关利塞膦酸盐与安慰剂治疗男性骨质疏松患者的随机对照试验。随访大于12个月,提供骨折发生率的文献纳入研究。分析入选文献的方法学质量,提取资料,用RevMan4.2软件进行荟萃分析。结果3篇文献符合纳入标准,包括780例男性骨质疏松患者。荟萃分析结果显示利塞膦酸盐可降低69%的椎体骨折风险(RR=0.31,95%CI:0.16,0.60)和58%的非椎体骨折风险(RR=0.42,95%CI:0.23,0.78)。结论利塞膦酸盐对男性骨质疏松症患者可提供良好的抗骨折效应。

引用

页码：659 / 662

页数：4

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