盐酸丁螺环酮治疗反社会人格障碍攻击行为对照研究

Objective:To evaluate the anti-aggressive effect of Buspirone in aggressive individuals with DSM-Ⅳ antisocial personality disorder.Methods:The Point-Subtraction Aggression Paradigm(PSAP) and the Modified Overt Aggression Scale (MOAS) were used to assess the anti-aggression effects of Buspirone in a case control study,in which 20 subjects with antisocial personality disorder were included in the study group with Buspirone treatment,and another 20 personality disorder subjects in cotrol group without drug.Results: The efficacy rate of study group assessed with MOAS was 100%,which was significantly higher than that of control group (25%) after four weeks of treatment.The efficacy rate assessed with PSAP-B response and PSAP-B response per point subtraction was 70% and 68.4% in study group,and 50% and 50% in control group.Conclusion:Buspirone treatment has an antiaggressive effect on DSM-Ⅳ antisocial personality disorder subjects.