Effect of HIF-1αon VEGF-C Induced Lymphangiogenesis and Lymph Nodes Metastases of Pancreatic Cancer

被引：20

作者：

陶京 ^{[1
]}

李弢 ^{[2
]}

李凯 ^{[1
]}

熊炯炘 ^{[1
]}

杨智勇 ^{[1
]}

吴河水 ^{[1
]}

王春友 ^{[1
]}

机构：

[1] Department of Pancreatic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China

[2] Department of Nephrology,Wuhan Children Hospital,Wuhan ,China

来源：

华中科技大学学报(医学英德文版) | 2006年 / 05期

关键词：

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

<正>The effect of hypoxia inducible factor-1α(HIF-1α) on vascular endothelial growth factor C (VEGF-C) and the correlation between HIF-1αand lymphangiogenesis and lymph nodes metasta-ses (LNM) in pancreatic cancer were investigated. Immunohistochemical SP method was used to detect the protein expression of HIF-1αand VEGF-C, and Lymphatic vessel density (LVD) was determined by stain of VEGFR-3, collagen type IV in 75 pancreatic head cancers from regional pancre-atectomy (RP) during Dec. 2001 to Dec. 2003. The relationship between HIF-1αand VEGF-C, lymphangiogenesis, LNM was analyzed statistically. The results showed that the positive expression rate of HIF-1αand VEGF-C in pancreatic cancer tissues was 48.00 % (36/75) and 65.33 % (49/75) respectively. In positive group of HIF-1α, the positive rate of VEGF-C and LVD, and LVD rate was 80.56 % (29/36), 13.22±3.76 and 88.89 % (32/36) respectively, and in negative group of HEF-1α, positive rate of VEGF-C and LVD was 51.28 % (20/39), 5.98±2.17 and 66.67 % (26/39) respectively (P<0.01 or P<0.05). It was suggested that HIF-1αcould promote the expression of VEGF-C, lymphangiogenesis and LNM in pancreatic cancer.

引用

页码：562 / 564

页数：3