Caspase-3在脑缺血神经元损伤中的作用

被引:16
作者
张拥波
罗勇
董为伟
机构
[1] 重庆医科大学神经病学研究所
关键词
脑缺血; caspase-3; 细胞色素C;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
Caspase 3属于白介素 1β转换酶家族 ,是哺乳动物细胞凋亡的关键蛋白酶。近来发现 ,caspase 3参与了脑缺血后神经元损伤的病理过程 ,在脑缺血中起重要作用。脑缺血后 ,神经元线粒体释放细胞色素C为caspase 3的激活创造了条件 ,同时脑缺血后出现caspase 3的表达和活性变化 ,caspase 3抑制剂可减轻脑缺血神经元的损害 ,这将为脑缺血提供新的治疗对策
引用
收藏
页码:79 / 81
页数:3
相关论文
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