糖尿病性黄斑水肿的药物治疗进展

被引:11
作者
康皓
徐延山
张红
苏龙
机构
[1] 天津医科大学眼科中心
关键词
糖尿病视网膜病变/治疗; 黄斑水肿/药物疗法; 综述文献;
D O I
暂无
中图分类号
R774.5 [黄斑、中心窝疾病]; R587.2 [糖尿病性昏迷及其他并发症];
学科分类号
100212 ; 1002 ; 100201 ;
摘要
糖尿病性黄斑水肿(DME)是导致糖尿病视网膜病变(DR)患者视力下降的主要原因之一。目前,激光光凝和玻璃体手术治疗已经明显降低了DR的致盲率,但二者对于改善视力的疗效、特别是对于糖尿病性黄斑水肿的疗效尚不能令人满意。随着对DR发病机制的深入研究,目前已开发出多种药物用于防治DR,特别是在治疗DME方面取得了一定的疗效,包括糖皮质激素、抗血管内皮生长因子药物、非甾体类药物、降血脂药物、血管紧张素抑制剂和选择性蛋白激酶C-β抑制剂。本文就近几年来药物治疗糖尿病性黄斑水肿的进展作一综述。
引用
收藏
相关论文
共 18 条
[1]   A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema [J].
Ip, Michael S. ;
Edwards, Allison R. ;
Beck, Roy W. ;
Bressler, Neil M. ;
Aiello, Lloyd Paul ;
Browning, David J. ;
Elman, Michael J. ;
Friedman, Scott M. ;
Ferris, Frederick L. ;
Glassman, Adam R. ;
Kollman, Craig ;
Price, Angela .
OPHTHALMOLOGY, 2008, 115 (09) :1447-1459
[2]  
Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial[J] . AC Keech,P Mitchell,PA Summanen,J O’Day,TME Davis,MS Moffitt,M-R Taskinen,RJ Simes,D Tse,E Williamson,A Merrifield,LT Laatikainen,MC d’Emden,DC Crimet,RL O’Connell,PG Colman.The Lancet . 2007 (9600)
[3]   Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes [J].
Sugiyama, Tetsuya ;
Okuno, Takashi ;
Fukuhara, Masayuki ;
Oku, Hidehiro ;
Ikeda, Tsunehiko ;
Obayashi, Hiroshi ;
Ohta, Mitsuhiro ;
Fukui, Michiaki ;
Hasegawa, Goji ;
Nakamura, Naoto .
EXPERIMENTAL EYE RESEARCH, 2007, 85 (03) :406-412
[4]  
Primary Intravitreal Bevacizumab (Avastin) for Diabetic Macular Edema[J] . J. Fernando Arevalo,Jans Fromow-Guerra,Hugo Quiroz-Mercado,Juan G. Sanchez,Lihteh Wu,Mauricio Maia,Maria H. Berrocal,Adriana Solis-Vivanco,Michel E. Farah.Ophthalmology . 2007 (4)
[5]   The therapeutic potential of VEGF inhibition in diabetic microvascular complications [J].
Tremolada, Gemma ;
Lattanzio, Rosangela ;
Mazzolari, Gabriella ;
Zerbini, Gianpaolo .
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2007, 7 (06) :393-398
[6]   A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema [J].
Scott, Ingrid U. ;
Edwards, Allison R. ;
Beck, Roy W. ;
Bressler, Neil M. ;
Chan, Clement K. ;
Elman, Michael J. ;
Friedman, Scott M. ;
Greven, Craig Michael ;
Maturi, Raj K. ;
Pieramici, Dante J. ;
Shami, Michel ;
Singerman, Lawrence J. ;
Stockdale, Cynthia R. .
OPHTHALMOLOGY, 2007, 114 (10) :1860-1867
[7]   Vascular endothelial growth factor is a critical stimulus for diabetic macular edema [J].
Nguyen, Quan Dong ;
Tatlipinar, Sinan ;
Shah, Syed Mahmood ;
Haller, Julia A. ;
Quinlan, Edward ;
Sung, Jennifer ;
Zimmer-Galler, Ingrid ;
Do, Diana V. ;
Campochiaro, Peter A. .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (06) :961-969
[8]   A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema [J].
Chun, Dal W. ;
Heier, Jeffrey S. ;
Topping, Trexler M. ;
Duker, Jay S. ;
Bankert, Joy M. .
OPHTHALMOLOGY, 2006, 113 (10) :1706-1712
[9]   A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration [J].
Nguyen, Quan Dong ;
Shah, Syed Mahmood ;
Hafiz, Gulnar ;
Quinlan, Edward ;
Sung, Jennifer ;
Chu, Karen ;
Cedarbaum, Jesse M. ;
Campochiaro, Peter A. .
OPHTHALMOLOGY, 2006, 113 (09) :1522-1532
[10]  
Glucocorticoid Regulation of Endothelial Cell Tight Junction Gene Expression: Novel Treatments for Diabetic Retinopathy[J] . Edward A. Felinski,David A. Antonetti.Current Eye Research . 2005 (11)