PI3K/Akt信号传导通路与肿瘤多药耐药研究进展

被引：30

作者：

张晔

刘云鹏

机构：

[1] 中国医科大学附属第一医院肿瘤内科

来源：

中华临床医师杂志(电子版) | 2011年 / 5卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

<正>磷脂酰肌醇3-激酶/蛋白激酶B[phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt),PI3K/Akt]信号传导通路作为细胞生存重要通路之一,在促进细胞生长、增殖,促进细胞运动、侵袭,抑制细胞凋亡,促进血管生成,抵抗化疗和放疗等方面起重要作用。近年来,关于PI3K/Akt信号通路与药物耐药性关系的研究越来越多,并被认为是化疗耐药治疗的新靶点。Akt是PI3K/Akt通路中的关键性效应分子,多种肿瘤组织中都有Akt的过度表达和活化。多项实验表明,化疗药物可增加Akt磷酸化水平,使肿瘤细胞产生化疗耐受

引用

页码：446 / 449

页数：4

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