阿托伐他汀对不同程度颈动脉粥样硬化患者外周血T淋巴细胞亚群的影响

被引：7

作者：

张津华

马丽丽

李江坤

苏建

赵春水

付志新

机构：

[1] 开封市中心医院神经内科

来源：

中华老年心脑血管病杂志 | 2014年 / 16卷 / 11期

关键词：

动脉粥样硬化; 颈动脉疾病; T淋巴细胞亚群; C反应蛋白质; 降血脂药;

D O I：

暂无

中图分类号：

R543.4 [颈动、静脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的观察不同程度的颈动脉粥样硬化(carotid artery sclerosis,CAS)患者外周血T淋巴细胞亚群的分布特点,以及阿托伐他汀对此的影响。方法选择CAS患者212例,按照CAS严重程度分为3组。轻度CAS组73例,中度CAS组96例,重度CAS组43例,每天口服20mg阿托伐他汀,观察治疗前和治疗6个月后的颈动脉内膜中层厚度(IMT)、CAS斑块的数量和稳定性、HDL-C、LDL-C、TG、高敏C反应蛋白(hs-CRP)、CD4T淋巴细胞、CD8T淋巴细胞和CD4/CD8比值变化。结果中度CAS组和重度CAS组治疗后IMT较治疗前明显降低[(1.77±1.26)mmvs(2.23±1.06)mm,(2.15±1.10)mmvs(2.61±1.31)mm,P<0.05]。3组治疗前后IMT和斑块性质比较,差异有统计学意义(P<0.01)。3组治疗前后LDL-C、CD4、CD8、CD4/CD8比较,差异有统计学意义(P<0.05,P<0.01);3组治疗前TG、hs-CRP比较,差异有统计学意义(P<0.05);与治疗前比较,3组治疗后LDL-C、TG、hs-CRP、CD8明显降低,HDL-C、CD4、CD4/CD8明显升高,差异有统计学意义(P<0.05,P<0.01)。结论阿托伐他汀治疗CAS的机制之一是调节T淋巴细胞亚群。

引用

页码：1137 / 1139

页数：3

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