紫癜性肾炎患儿血清sFlt-1、vWF水平变化及其意义

被引：5

作者：

代彦林 ^{[1
]}

张霞 ^{[2
]}

高敏 ^{[2
]}

韩姗姗 ^{[1
,2
]}

丁樱 ^{[1
,2
]}

机构：

[1] 河南中医药大学

[2] 河南中医药大学第一附属医院

来源：

山东医药 | 2021年 / 61卷 / 12期

关键词：

紫癜性肾炎; 可溶性血管内皮生长因子受体-1; 血管性血友病因子;

D O I：

暂无

中图分类号：

R726.9 [小儿泌尿科学];

学科分类号：

100202 [儿科学];

摘要：

目的观察紫癜性肾炎(HSPN)患儿血清可溶性血管内皮生长因子受体-1(sFlt-1)、血管性血友病因子(vWF)水平变化,并探讨其临床意义。方法 HSPN患儿45例(HSPN组),过敏性紫癜(HSP)患儿15例(HSP组),同期健康体检儿童15例(对照组),采用酶联免疫吸附法检测各组血清sFlt-1、vWF,Pearson相关分析法分析HSPN组患儿血清sFlt-1与vWF水平的相关性。结果与对照组比较,HSPN组及HSP组血清sFlt-1、vWF水平升高(P均<0.05);与HSP组比较,HSPN组血清sFlt-1、vWF水平升高(P均<0.05)。HSPN组血清sFlt-1与vWF水平无相关性(r=-0.24,P=0.180)。结论 HSPN患儿血清sFlt-1、vWF水平升高,两者可能参与HSP早期肾脏损伤。

引用

页码：51 / 53

页数：3

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