温郁金对VEGF和MVD在人胃癌裸小鼠移植瘤中表达的研究

被引：14

作者：

王佳林

吕宾

倪桂宝

麻林爱

徐毅

机构：

[1] 浙江省中医院消化科

来源：

肿瘤 | 2005年 / 01期

关键词：

胃肿瘤; 温郁金; 血管内皮生长因子; 微血管密度; 异种移植模型肿瘤试验; 小鼠,裸;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

摘要：

目的　研究温郁金对人胃癌裸鼠移植瘤生长的抑制作用和对血管内皮生长因子(VEGF)的表达和微血管密度(MVD)的影响。方法　采用人胃癌SGC7901细胞株种植裸小鼠皮下建立胃癌移植瘤模型。自肿瘤种植后,待肿瘤生长到2mm时开始给药,每日2次,连续7周,每周测量瘤体的大小。第7周处死动物,测定肿瘤重量,免疫组化ElivisionTMplus法测定VEGF及肿瘤内MVD。结果　温郁金治疗组瘤重和体积明显低于对照组,VEGF表达的程度和MVD计数明显低于对照组。结论　温郁金对人胃癌裸鼠移植瘤的生长具有明显的抑制作用,可下调瘤灶中VEGF的表达,减少肿瘤灶内的MVD。

引用

页码：55 / 57

页数：3

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