Survivin、PTEN在子宫肌瘤中的表达及相关性研究

被引:10
作者
武孟香
高英敏
王秀华
刘玉琴
机构
[1] 兰州医学院第一附属医院妇产科
关键词
子宫肌瘤; 免疫组化; 图像分析; Survivin; PTEN;
D O I
暂无
中图分类号
R737.33 [子宫肿瘤];
学科分类号
摘要
目的 探讨survivin与PTEN在子宫肌瘤中的表达和意义及其相关性。方法 用免疫组化S-P法和图像分析技术检测 20例正常子宫肌层(NM)组织和 40例子宫肌瘤(UL)组织中Survivin和PTEN蛋白的表达情况。结果 Survivin在UL中的阳性率和表达强度明显高于NM(χ2 =7. 576, p=0. 006; t=-4.574, p=0. 000);PTEN在UL中的表达强度显著低于NM(t′=8. 436, p=0. 000);在UL中Survivin与PTEN的表达强度呈负相关(r=-0. 434, p=0. 005)。结论 Survivin和PTEN可能在UL细胞的凋亡和增殖中发挥协同作用,共同参与UL的发生发展。
引用
收藏
页码:52 / 54
页数:3
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