膝骨性关节炎慢性疼痛的机制及其综合治疗进展

被引:27
作者
彭昊
张雷
廉凯
陈森
机构
[1] 武汉大学人民医院骨关节外科
关键词
膝骨性关节炎; 慢性疼痛; 外周疼痛机制; 中枢疼痛机制; 神经生长因子; 抗NGF抗体;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
膝骨关节炎(KOA)是慢性疼痛最常见的原因之一,其治疗仅限于对乙酰氨基酚、非甾体抗炎药和物理治疗等,全膝关节置换术是解决关节疼痛的最终选择。因此,对于KOA疼痛的产生机制需进一步了解,以希望找到更好的治疗方法。
引用
收藏
页码:476 / 478
页数:3
相关论文
共 13 条
[1]
物理因子治疗膝关节骨性关节炎的临床疗效及其对患者生活质量的影响 [J].
周峰 ;
刘尊武 .
按摩与康复医学, 2015, 6 (08) :62-63
[2]
广州地区15岁及以上人群骨关节炎流行病学特征及危险因素分析 [J].
张思恒 ;
董晓梅 ;
叶云凤 ;
王海清 ;
饶珈铭 ;
陈雄飞 ;
吴雪霁 ;
利耀辉 ;
潘冰莹 ;
王声湧 .
中华疾病控制杂志, 2015, 19 (01) :9-12
[3]
膝关节骨性关节炎中医治疗模式研究进展 [J].
李冉 ;
白岚 ;
李树祝 .
现代中西医结合杂志, 2014, 23 (01) :104-107
[4]
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art; current prospects; and future challenges.[J].Maryam Rahmati;Ali Mobasheri;Masoud Mozafari.Bone.2016,
[5]
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib [J].
Hochberg, Marc C. ;
Martel-Pelletier, Johanne ;
Monfort, Jordi ;
Moeller, Ingrid ;
Ramon Castillo, Juan ;
Arden, Nigel ;
Berenbaum, Francis ;
Blanco, Francisco J. ;
Conaghan, Philip G. ;
Domenech, Gema ;
Henrotin, Yves ;
Pap, Thomas ;
Richette, Pascal ;
Sawitzke, Allen ;
du Souich, Patrick ;
Pelletier, Jean-Pierre .
ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (01) :37-44
[6]
Annual Incidence of Knee Symptoms and Four Knee Osteoarthritis Outcomes in the Johnston County Osteoarthritis Project [J].
Murphy, Louise B. ;
Moss, Susan ;
Do, Barbara T. ;
Helmick, Charles G. ;
Schwartz, Todd A. ;
Barbour, Kamil E. ;
Renner, Jordan ;
Kalsbeek, William ;
Jordan, Joanne M. .
ARTHRITIS CARE & RESEARCH, 2016, 68 (01) :55-65
[7]
Influence of sleep deprivation and circadian misalignment on cortisol; inflammatory markers; and cytokine balance.[J].Kenneth P. Wright;Amanda L. Drake;Danielle J. Frey;Monika Fleshner;Christopher A. Desouza;Claude Gronfier;Charles A. Czeisler.Brain Behavior and Immunity.2015,
[8]
A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee.[J].T.J. Schnitzer;J.A. Marks.Osteoarthritis and Cartilage.2015, Suppl.1
[9]
Structural Associations of Symptomatic Knee Osteoarthritis [J].
Stoppiello, Laura A. ;
Mapp, Paul I. ;
Wilson, Deborah ;
Hill, Roger ;
Scammell, Brigitte E. ;
Walsh, David A. .
ARTHRITIS & RHEUMATOLOGY, 2014, 66 (11) :3018-3027
[10]
Psychological Profiles and Pain Characteristics of Older Adults With Knee Osteoarthritis [J].
Cruz-Almeida, Yenisel ;
King, Christopher D. ;
Goodin, Burel R. ;
Sibille, Kimberly T. ;
Glover, Toni L. ;
Riley, Joseph L. ;
Sotolongo, Adriana ;
Herbert, Matthew S. ;
Schmidt, Jessica ;
Fessler, Barri J. ;
Redden, David T. ;
Staud, Roland ;
Bradley, Laurence A. ;
Fillingim, Roger B. .
ARTHRITIS CARE & RESEARCH, 2013, 65 (11) :1786-1794