重症急性胰腺炎合并胃肠损害机制的研究进展附视频

被引：5

作者：

余珊

周贤

机构：

[1] 泸州医学院附属医院

来源：

山东医药 | 2015年 / 45期

关键词：

重症急性胰腺炎; 胃肠动力障碍; 胃肠黏膜损害;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

急性胰腺炎尤其是重症急性胰腺炎(SAP)患者早期常出现胃肠功能障碍和黏膜病变。SAP并胃肠动力障碍与神经因素、NO过量、胃肠激素变化、炎症介质过量表达、消化系Cajal间质细胞缺失、胰腺炎相关性腹水等有关,SAP并发消化性溃疡的机制仍不完全清楚,多数研究认为与胰腺本身病变所致的黏膜损害因素加重和抗损害能力的削弱有关。胰腺坏死、脓毒症、APACHEⅡ评分、胰腺脓肿、胰腺囊肿和器官衰竭均是SAP合并消化道出血的高危因素。

引用

页码：102 / 105

页数：4

共 16 条

[1]

Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats[J] Liang-Liang Shi;Ming-Dong Liu;Min Chen;Xiao-Ping Zou; World Journal of Gastroenterology 2013,

[2]

清胰汤改善重症急性胰腺炎大鼠胃肠动力的机制研究 [J].

王强 ;

唐才喜 ;

王湘英 ;

冯斌 ;

杨凯庆 ;

贺明连 ;

赵志坚 .

中国普通外科杂志, 2013, 22 (03) :275-280

[3]

Association between acute pancreatitis and peptic ulcer disease[J] Kang-Moon Lee;Chang-Nyol Paik;Woo Chul Chung;Jin Mo Yang; World Journal of Gastroenterology 2011,

[4]

伴有胃肠动力障碍的重症急性胰腺炎大鼠结肠肠肌间神经丛一氧化氮合成酶神经元的变化 [J].

刘颖 ;

林中 ;

胡琼花 ;

郑清华 .

第三军医大学学报, 2010, 32 (03) :274-277

[5]

Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility[J] Tor C Savidge Current Opinion in Pharmacology 2014,

[6]

Toward a better understanding of gastrointestinal nitrergic neuromuscular transmission[J] B. Lies;D. Groneberg;A. Friebe Neurogastroenterol. Motil. 2014,

[7]

Nutritional management of acute pancreatitis: the concept of ‘gut rousing’[J] Maxim S. Petrov;John A. Windsor Current Opinion in Clinical Nutrition and Metabolic Care 2013,

[8]

Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study[J] Annika Reintam Blaser;Martijn Poeze;Manu L. N. G. Malbrain;Martin Bj?rck;Heleen M. Oudemans-van Straaten;Joel Starkopf Intensive Care Medicine 2013,

[9]

IL-6; TNF-α; and iNOS is associated with decreased colonic contraction in rats with multiple organ dysfunction syndrome[J] Ang Li;Junjie Xiong;Zheyu Chen Journal of Surgical Research 2012,

[10]

Damage of the interstitial cells of Cajal and myenteric neurons causing ileus in acute necrotizing pancreatitis rats[J] Hui Zhou;Li Liu;Yu Bai;Wenbin Wu;Guixiang Li;Jianping Li;Duowu Zou;Jun Gao;Zhaoshen Li Surgery 2011,

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