顺铂类配合物肝毒性的自由基机理研究

被引:2
作者
卢景雰
王夔
郭宇姝
张宇涛
徐波
刘宏宇
机构
[1] 北京医科大学天然药物及仿生药物国家重点实验室,北京医科大学天然药物及仿生药物国家重点实验室,北京医科大学天然药物及仿生药物国家重点实验室,北京医科大学天然药物及仿生药物国家重点实验室,北京医科大学天然药物及仿生药物国家重点实验室,北京医科大学天然药物及仿生药物国家重点实验室北京,北京,北京,北京,北京,北京
关键词
顺铂; 肝毒性; 自由基; 电子自旋共振; 脂质过氧化;
D O I
暂无
中图分类号
R114 [卫生毒理];
学科分类号
100405 ;
摘要
运用自旋捕捉电子自旋共振技术直接捕捉到兔肝、肾微粒体脂质过氧化形成的脂自由基L?,体外亚细胞水平的实验研究表明各种顺铂类配合物促进L?形成的作用和MDA的增长,血浆抗坏血酸(VC)库水平及血液GSH-Px活性的降低呈相似的变化趋势。作用的强弱与配合物的化学结构有关。顺铂的肝毒性与肾毒性一样,可能与自由基介导的氧化性损伤有关。
引用
收藏
页码:57 / 62
页数:6
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