胆汁淤积导致肝纤维化的机制及其阻断策略

被引：28

作者：

陈瑞玲

马雄

机构：

[1] 上海交通大学医学院附属仁济医院消化内科上海市消化病研究所

来源：

临床肝胆病杂志 | 2019年 / 35卷 / 02期

关键词：

胆汁淤积; 肝硬化; 胆汁酸类和盐类;

D O I：

暂无

中图分类号：

R575.22 [];

学科分类号：

摘要：

胆汁淤积是指胆汁流形成、分泌和排泄障碍的一种病理状态,而肝纤维化是肝损伤引起的组织修复过程。胆汁淤积性肝病是由胆汁淤积、胆管渐进性破坏和肝内炎症持续存在所导致的一种慢性肝病,引起胆管细胞和肝细胞损伤,并逐步进展为肝纤维化。结合目前的研究进展,对胆汁淤积导致肝纤维化的发生机制和阻断策略作一综述。

引用

页码：247 / 251

页数：5

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