骨髓微环境对造血干细胞静息的调节机制

被引：5

作者：

李欢

饶青

机构：

[1] 中国医学科学院、北京协和医学院血液学研究所、血液病医院,实验血液学国家重点实验室

来源：

中国细胞生物学学报 | 2015年 / 37卷 / 01期

关键词：

造血干细胞; 自我更新; 静息状态; 骨髓微环境;

D O I：

暂无

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

自我更新、多向分化和静息状态是造血干细胞的重要特征,其中静息状态的维持是维持造血干细胞数量及造血干细胞池稳定的重要机制。骨髓微环境是造血干细胞定居的场所,是维持造血干细胞静息必要的土壤,尤其是成骨细胞微环境可通过多种跨膜分子信号通路、黏附分子等调节造血干细胞的静息。造血干细胞静息关系到造血干细胞自我更新的平衡,其失衡与白血病的发生及白血病干细胞的干性维持相关。该文通过总结近几年最新研究进展并结合作者实验室的研究成果,对介导骨髓微环境调节造血干细胞静息的主要分子机制作一综述。

引用

页码：154 / 160

页数：7

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