高血压患者动脉缓冲功能和内皮调节功能临床研究

被引：16

作者：

王宏宇

张维忠

龚兰生

机构：

[1] 上海第二医科大学附属瑞金医院上海市高血压研究所!

来源：

心肺血管病杂志 | 2000年 / 01期

关键词：

高血压; 动脉; 扩张性; 内皮功能;

D O I：

暂无

中图分类号：

R544.1 [高血压];

学科分类号：

摘要：

研究高血压患者动脉缓冲功能和内皮调节功能的损害 ,为临床选择敏感反映高血压患者预后危险性的指标。对 54例原发性高血压患者和 16例正常人应用自动脉搏波速度 (PulsewavevelocityPWV)测定仪进行检测 ,颈动脉 -股动脉PWV(CPWV)作为反映动脉扩张性 (Distensibility)的参数 ,并能敏感反映动脉缓冲功能的改变。二维超声分别测定肱动脉横断面顺应性 (CSC) ,容积扩张性 (VD)和内皮依赖性血管扩张功能用于评价动脉缓冲功能和内皮功能。CPWV在高血压组显著升高 (P =0 .0 4 83) ,CSC ,VD高血压组显著低于正常对照组(P =0 .0 30 2 ,P =0 .0 196 ) ,内皮依赖性血管扩张功能在高血压组显著降低 (P =0 .0 130 )。多因素分析结果表明VD是与内皮功能关系最为密切的因素 (r =0 .3995,P =0 .0 0 11)。结论为高血压可导致动脉缓冲功能和内皮功能的损害 ,内皮功能障碍是动脉缓冲功能降低的原因。二维超声检测动脉扩张性的改变能敏感反映高血压患者动脉缓冲功能和内皮功能的损害 ,为临床提供了一个重要的无创指标 ,具有广阔的应用价值。

引用

页码：48 / 52

页数：5

共 12 条

[1] Relation of blood pressure and body build to left ventricular mass in normotensive and hypertensive employed adults. Hammond ZW,Devereux RB,Alderman MH,et al. Journalism Assn of Community College . 1988
[2] Effects of angiotensin converting enzyme inhibition on endothelium - dependent vasodilatation in essential hypertensive patients. Taddei S,Virdis A,Ghiadoni L,et al. Journal of Hypertension . 1998
[3] Shear stress abnormalities contribute to endothelial dysfunction in hypertension but not in type Ⅱ diabetes. Khder Y,Briancon S,Petermann R,et al. Journal of Hypertension . 1998
[4] Comparsion of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease. Enderle MD,Schroeder S,Ossen R,et al. Heart . 1998
[5] The role of endothelium in human hypertension. Taddei S,Virdis A,Ghiadoni L,et al. Current Opinion in Nephrology and Hypertension . 1998
[6] Arteries, myocardium, blood pressure and cardiovascular risk: towards a revised definition of hypertension. Cohn JN. Journal of Hypertension . 1998
[7] Additional benefits of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemicmen. Neunteufl T,Kostner K,Katzenschlager R,et al. Journal of the American College of Cardiology . 1998
[8] Effects of blood pressure control on radial artery diameter and compliance in hypertensive patients. Khder Y,Bray DL,Aliot E,et al. American Journal of Hypertension . 1997
[9] Impaired endothelial function with essential hypertension assessed by ultrasonography. Iiyama K,Nagano M,Yo Y,et al. American Heart Journal . 1996
[10] Structural abnormalities and not diastolic dysfunction are the earliest left ventricular changes in hypertension. Palatini P,Visentin P,Mormino P,et al. American Journal of Hypertension . 1998

← 1 2 →