In vivo Dynamic Studies of Brain Metabolism

被引：4

作者：

罗雪春

蒋玉凤

张日清

机构：

[1] State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China ,Department of Pathology, Beijing University of Chinese Medicine, Beijing 100029, China ,Department of Biological Sciences and Biotechnology, Tsinghu

[2] Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China

来源：

Tsinghua Science and Technology | 2005年 / 04期

关键词：

nuclear magnetic resonance (NMR); surface coil; ischemia-reperfusion; herbs;

D O I：

暂无

中图分类号：

R318.01 [生物力学];

学科分类号：

0831 ;

摘要：

Nuclear magnetic resonance (NMR) can noninvasively monitor intracellular concentrations and kinetic properties of numerous inorganic and organic compounds. A 31P NMR surface coil was used in vivo to dynamically measure phosphocreatine (PCr), adenosine triphosphate (ATP), and intracellular inorganic phosphate (Pi) levels in mouse brain during ischemia-reperfusion to study the damage of cerebral tissues caused by ischemia and effects of herbs on cerebral energy metabolism during ischemia-reperfusion. The study provides dynamic brain energy metabolism data during different periods. The data show that some herbs more rapidly increase the PCr level during the recovery phase than in the control group.

引用

页码：496 / 498

页数：3