自噬与肿瘤干细胞的研究进展

被引：5

作者：

张璐璐 ^{[1
,2
]}

张月英 ^{[1
,2
]}

张维东 ^{[1
,2
]}

机构：

[1] 山东省医学科学院基础医学研究所病理研究室

[2] 济南大学山东省医学科学院医学与生命科学学院

来源：

国际肿瘤学杂志 | 2014年 / 41卷 / 04期

关键词：

自噬; 肿瘤干细胞; 肿瘤;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

细胞自噬是以细胞质空泡化为特征的溶酶体依赖性降解途径,对维持细胞内环境稳定有重要意义,异常自噬与肿瘤发生密切相关。肿瘤干细胞是存在于肿瘤组织中一类数量较少但具有干细胞特性的肿瘤细胞,可诱导肿瘤发生并对肿瘤的发展、转移、复发起重要作用。肿瘤干细胞中自噬的调节已成为研究热点,将为肿瘤的临床治疗提供新的理论依据。

引用

共 9 条

[1]

Human mesenchymal stem cells enhance autophagy of lung carcinoma cells against apoptosis during serum deprivation [J].

Zhang, Ming-Hui ;

Hu, Yi-De ;

Xu, Yu ;

Xiao, Yu ;

Luo, Yan ;

Song, Zong-Chang ;

Zhou, Jing .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (04) :1390-1398

[2]

The roles of BECN1 and autophagy in cancer are context dependent [J].

Gong, Chang ;

Song, Erwei ;

Codogno, Patrice ;

Mehrpour, Maryam .

AUTOPHAGY, 2012, 8 (12) :1853-1855

[3]

Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells [J].

Trang Thi Mai ;

Moon, JeongYong ;

Song, YeonWoo ;

Pham Quoc Viet ;

Pham Van Phuc ;

Lee, Jung Min ;

Yi, Tae-Hoo ;

Cho, Moonjae ;

Cho, Somi Kim .

CANCER LETTERS, 2012, 321 (02) :144-153

[4]

Molecular Machinery of Autophagy and Its Implication in Cancer [J].

Li, Yumin ;

Zhang, Junqiang ;

Chen, Xiaohui ;

Liu, Tao ;

He, Wenting ;

Chen, Yingtai ;

Zeng, Xiangting .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2012, 343 (02) :155-161

[5]

Breast Cancer Stem Cells Survive Periods of Farnesyl-Transferase Inhibitor-Induced Dormancy by Undergoing Autophagy.[J].Moumita Chaterjee;Kenneth L. van Golen;Ross Brown.Bone Marrow Research.2011,

[6]

Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors.[J].Bruno Calabretta;Paolo Salomoni.Leukemia & Lymphoma.2011, S1

[7]

Autophagy: cellular and molecular mechanisms [J].

Glick, Danielle ;

Barth, Sandra ;

Macleod, Kay F. .

JOURNAL OF PATHOLOGY, 2010, 221 (01) :3-12

[8]

Role of autophagy in suppression of inflammation and cancer.[J].Eileen White;Cristina Karp;Anne M Strohecker;Yanxiang Guo;Robin Mathew.Current Opinion in Cell Biology.2009, 2

[9]

Autophagy: a regulated bulk degradation process inside cells.[J].Tamotsu Yoshimori.Biochemical and Biophysical Research Communications.2003, 2

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